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View Structure Prediction Details

Protein: SPAC1527.03
Organism: Schizosaccharomyces pombe
Length: 475 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPAC1527.03.

Description E-value Query
Range
Subject
Range
gi|94390383 - gi|94390383|ref|XP_910122.2| PREDICTED: similar to La ribonucleoprotein domain family, member 1 [Mus...
203.0 [0..97] [471..204]
gi|119625592, gi... - gi|30061569|ref|NP_115615.2| La ribonucleoprotein domain family member 2 isoform 3 [Homo sapiens], g...
199.0 [0..112] [445..2]
gi|109079486 - gi|109079486|ref|XP_001112050.1| PREDICTED: similar to la related protein isoform 1 isoform 3 [Macac...
195.0 [0..25] [471..8]
gi|109488127 - gi|109488127|ref|XP_220446.4| PREDICTED: similar to la related protein isoform 2 [Rattus norvegicus]
191.0 [0..55] [471..144]
gi|76623640 - gi|76623640|ref|XP_582017.2| PREDICTED: similar to la related protein [Bos taurus]
190.0 [0..82] [471..11]
gi|50755001 - gi|50755001|ref|XP_414577.1| PREDICTED: similar to KIAA0731 protein [Gallus gallus]
189.0 [0..63] [471..618]

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Predicted Domain #1
Region A:
Residues: [1-94]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHKEPSAAE TSTVVHSEED KAFCIGTGAV ISEEREKEVL KNLQNSLTGK TAEENLNDEA  60
   61 NHTSSDKSKS EDYQPSNVNV WALRKEKMIP KKHS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [95-233]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HVKQEKRFSK SLQLQDPNVW PSPEIAEKQV EDRKLSDDSQ KPLAPKANGK EKWVTITPNF  60
   61 THTPISNRKS SRSRNDGSRR NGNGRRRGNY SSHGSNKRQT NYSREKDASR SIDSSNPSAE 120
  121 YRDDINNTFG SQTVSSANG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [234-316]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KEVPQTSEDS SSQAPHHSSS SGHAPSQQGG NKHSYKKSDS QQSFHHKGRN TRKGQRHNNG  60
   61 FYRNIANNIQ GPFPNYPVVV NGN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [317-475]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVNPYLCDVQ AFLTSQLEYY FSIENLCKDM FLRKHMDDEG YVPLAFLASF NRIKSFSTDL  60
   61 NLLHAACKAS DIIDVAIDLQ SPMSIKVRRK ETWSPWILPS ESRLKFEMAK YPQINSSSSM 120
  121 SPLASSISNL TISPPFIPSS VDSIIKRDVQ TEVEDKLTV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.0
Match: 1ytyA
Description: Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.16805061653531 bayes_pls_golite062009
nucleic acid binding 3.10560219735181 bayes_pls_golite062009
DNA binding 2.97348943886804 bayes_pls_golite062009
structural constituent of ribosome 2.95301685898669 bayes_pls_golite062009
structural molecule activity 2.70976099158766 bayes_pls_golite062009
binding 2.29601364076827 bayes_pls_golite062009
transcription factor activity 2.27922300995509 bayes_pls_golite062009
sequence-specific DNA binding 0.93130370844712 bayes_pls_golite062009
transcription activator activity 0.782193398686323 bayes_pls_golite062009
transcription repressor activity 0.67795138236883 bayes_pls_golite062009
RNA binding 0.345456982950223 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.10854873707001 bayes_pls_golite062009
protein binding 0.057263185425224 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle