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View Structure Prediction Details

Protein: rgf3
Organism: Schizosaccharomyces pombe
Length: 1275 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for rgf3.

Description E-value Query
Range
Subject
Range
gi|67537098, gi|... - gi|67537098|ref|XP_662323.1| hypothetical protein AN4719.2 [Aspergillus nidulans FGSC A4], ref|XP_40...
580.0 [0..2] [1267..49]
gi|114191837, gi... - gi|115398730|ref|XP_001214954.1| hypothetical protein ATEG_05776 [Aspergillus terreus NIH2624], gi|1...
567.0 [0..11] [1266..33]
gi|32408735, gi|... - gi|32408735|ref|XP_324848.1| hypothetical protein [Neurospora crassa], gi|28927621|gb|EAA36572.1| hy...
gi|85074881 - gi|85074881|ref|XP_965808.1| hypothetical protein NCU00668.1 [Neurospora crassa OR74A]
563.0 [0..1] [1268..61]
gi|169778969 - gi|169778969|ref|XP_001823949.1| hypothetical protein [Aspergillus oryzae RIB40]
gi|83772688 - gi|83772688|dbj|BAE62816.1| unnamed protein product [Aspergillus oryzae]
561.0 [0..3] [1267..44]
gi|70998102, gi|... - gi|70998102|ref|XP_753782.1| Rho guanyl nucleotide exchange factor (Rom2) [Aspergillus fumigatus Af2...
555.0 [0..7] [1266..32]
RGF1_SCHPO - Rho1 guanine nucleotide exchange factor 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=...
rgf1 - RhoGEF for Rho1, Rgf1
547.0 [0..28] [1248..130]
gi|88182284, gi|... - gi|88182284|gb|EAQ89752.1| conserved hypothetical protein [Chaetomium globosum CBS 148.51], gi|11619...
538.0 [0..11] [1268..123]
gi|111070391 - gi|111070391|gb|EAT91511.1| hypothetical protein SNOG_00016 [Phaeosphaeria nodorum SN15]
535.0 [0..19] [1253..421]

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Predicted Domain #1
Region A:
Residues: [1-374]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLSNELFHR SSKDHGGKSR ICLDSSEDTY PPHSSSPPSF QKRLSFSDFS TTRLFSPPFL  60
   61 SKRSNNSPHR FSYSPPQHPA SINSRRVASY TVQSSPSRTT YRQLPNEPQN SAAYTTYSSF 120
  121 PNALFDDFSP NNPLDTDPFL TSPGNKQNTV DSFRPLPETP VSPGGSLVHP LPRPPLPSSV 180
  181 SSHSSPYSTT SSTSLYSLYN DISLSCSPEP YLPLSPTRSP ARTPSPIRLY SSDALRPQSP 240
  241 LSPSVEYLTP PNPYSLKSDI SSTRQLPKIP VQDYASGKIS SPLITRTHRR AQSETLFSSC 300
  301 REPWLVGKLY KWCKEEVFTA LGGLVHEGVS RREVAQVMAT LFTIHIASME FLIAEIIAKN 360
  361 ILGDWINYGL VEVI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.69897
Match: 1y0fA
Description: No description for 1y0fA was found.

Predicted Domain #2
Region A:
Residues: [375-462]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLEKLQIAFT SNEPPSGSGV LPFLTNGGCY SYICRSRSCP SKYQCYSCRC ARNSSLEFTS  60
   61 LPGQSSDTWS IFWNISSLNS LPSSLSKR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 87.154902
Match: 2pz1A
Description: No description for 2pz1A was found.

Predicted Domain #3
Region A:
Residues: [463-987]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EIARQNNIHE LICKESDYVA DLNTLAELFR DGIVQQQDAI VPSNRVADFI QSVFGNVESI  60
   61 RQLHSRLFLP QLIMRERLQG PVVSIIGDIL LEWIHAAKSS YINYAKQFPL ADETYKLECQ 120
  121 RNTYFARWLA ACRSDPRCRR LDFQHFLQRP TQRLQRYTLE LDTILKHTEQ SSWDFQLITQ 180
  181 AVKELRATCE ECDAVIATVL EANRIRDLSY QLLFKNHESV NLELRDPERE FFFEGIVQRR 240
  241 SDSRLDWLDI HLFLLDNYLI MAKARKDKRT NASRYVVSKR PIPLDLLVLS PKMDDFQLKS 300
  301 NTNKFLGSLA GNLPQESLTT KSKRKSKVNL ELMFDATAEK NNENSMNSAV FEKSQLYPFT 360
  361 IRHLGAYTAS YTLYVESLQL RKLWVEKINV AKKRHSQKIN IKNPFALKVV SDVAFQYPPS 420
  421 DLVNGNEPLN SFNEITLVEG SSIDRALNEV AWKHPIVSEE LLPEPIAYGD ISCIAQFNDY 480
  481 EGHVSVLIAT STGIFLGAFG DSSDIRDWKK ISSQRRVTQL GVVEE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 28.69897
Match: 1xdvA
Description: Experimentally Phased Structure of Human the Son of Sevenless protein at 4.1 Ang.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.65091781683225 bayes_pls_golite062009
protein binding 2.12168271674167 bayes_pls_golite062009
GTPase regulator activity 1.66986263418539 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.64990514605397 bayes_pls_golite062009
Rho guanyl-nucleotide exchange factor activity 1.31154393866945 bayes_pls_golite062009
small GTPase regulator activity 1.2550809703725 bayes_pls_golite062009
enzyme regulator activity 1.25381967078645 bayes_pls_golite062009
small GTPase binding 0.8507658747425 bayes_pls_golite062009
GTPase binding 0.82889812790119 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.745321902095093 bayes_pls_golite062009
transcription regulator activity 0.66119387669652 bayes_pls_golite062009
nucleic acid binding 0.593146992671847 bayes_pls_golite062009
DNA binding 0.48667544658785 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [988-1128]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDILLELRDK TLYAHKLSRI IEMGLIESKI AVVIGTPHAV SFFKIGKLSE GASVKRERTL  60
   61 VFYKEGLGNT TTIICCEPVI GLGHNYQKTY AFKRKDVTSF RTLDDFHVTA NCHSIDCFKY 120
  121 SIALCHNKGI DVLRLDPKLA V

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [1129-1275]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GFPSPSVLND TLFRNRINNS KPLGVFRIHD PSLFACCYQF GAVFVNGEGS MVNKECWFDW  60
   61 IGKPNSVTSC HGYLIAFNDE FVEIWNTRTR KLNQIIQGND IKYYPSNSDW LANGKYIMFG 120
  121 MVHPQYHDRH LILALNKAKT NSFIIED

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle