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View Structure Prediction Details

Protein: SPBC2F12.05c
Organism: Schizosaccharomyces pombe
Length: 1310 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC2F12.05c.

Description E-value Query
Range
Subject
Range
gi|22035612 - gi|22035612|ref|NP_665682.1| oxysterol-binding protein-like protein 6 isoform b [Homo sapiens]
625.0 [0..381] [1300..1]
OSBL6_MOUSE - Oxysterol-binding protein-related protein 6 OS=Mus musculus GN=Osbpl6 PE=1 SV=1
614.0 [0..391] [1300..32]
gi|76609395 - gi|76609395|ref|XP_872029.1| PREDICTED: similar to oxysterol-binding protein-like protein 6 isoform ...
614.0 [0..365] [1300..9]
gi|74004722 - gi|74004722|ref|XP_850789.1| PREDICTED: similar to oxysterol-binding protein-like protein 6 isoform ...
611.0 [0..391] [1300..32]
gi|114581946 - gi|114581946|ref|XP_515939.2| PREDICTED: oxysterol-binding protein-like protein 6 isoform 9 [Pan tro...
608.0 [0..391] [1300..32]

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Predicted Domain #1
Region A:
Residues: [1-467]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEHPSPDSVS STSSSDHKKA ELSDSLKQLQ LLQAFQAGDI KQVDNLLHNK SKDECTHALF  60
   61 ISIQCANVQM VKHILSVFDV DVNAYDKNKN TPLHLAAMAG RQDIVEALLL HPDINYNLVN 120
  121 ANNKKAYQVA TSPQLMDFMK GFYVTYTKET AREFKKAFKE RNLESMDYLM RHNEFNDAID 180
  181 LNEVDIKTGQ TYLHVATKAK DAELVKWLLD NGADPYRRDK FGKLPTDYTK DENMRSLLRS 240
  241 YSGNRDSSSA PAVPQHMSGY LKKWTNYKSG YKLRWFTLNN GVLSYYKNQD DASSACRGSI 300
  301 NLKLARLVHD PKQPTVFQVI GKGSVRYSVK ANSPVEAKKW IAAISSAIEN DEEANKPNVT 360
  361 ADNASFGTHD LAPAAHKFTQ SNASGNSGWD DNESDIDRAQ LPSRENFEFN VNIAKLQVET 420
  421 LHKLIDSAMQ TEKVKKDPSL SQVFDGISNS FNTLHKTVLE MLDLQRQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 66.69897
Match: 1n11A
Description: Ankyrin-R
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.74306164317133 bayes_pls_golite062009
protein binding 1.6716587413544 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [468-694]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEHYYKRKLD NAKAINALWA ENLKTVVEEQ DQIEERYHRS EAHRRRTKRA FRRLAASLKK  60
   61 RPSDKDNKLH IHYDDGAMSS TSYSTDFTDD EEETNTKDEF FDVDAHDNNH ANKAEPSQTA 120
  121 NNVHEIREPS FSSEHKPQPS LKTTTDVSSP ETKQNIADIR KTTLTDQTEE FTERRDNNGS 180
  181 IPSKQPSDEQ HLGKESLPSQ QSTVSNHHRK ESIPSKQPTE GQHARQE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [695-917]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLPSQQTTET KHLRKESTPS KQPTEGQHTR QESLPSQQTT ETKHLRKESI PSKQPTEGQH  60
   61 ARQESLPSQQ TTETKHLRKE SIPSKQPSGG QQLRQESLPS QQSSESKQST QHQQPVEVQK 120
  121 SIQSDVSAPK AKEVSEKPVS HQAKPSNASQ LSRNTDDTQA KEAPKEASIP DNASTASTKV 180
  181 SNDSHLKPDA DKKSVSSELT HASKPSLDEK TMQLAKQIAV SFH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [918-1310]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GYEAPTRENL DVNDDRPKIS LWGILKGMIG KDMTKMTLPV SFNEPTSLLQ RVAEDMEYTE  60
   61 LLDQASHNKD PYQRILYVAA FAASEYASTL NRVAKPFNPL LGETYEFCHP QRGFRFIVEQ 120
  121 VSHHPPVGAA YSESANWKYY GESSVKSKFY GKSFDISPLG TWFLELRHPS GEVELYTWKK 180
  181 VTSSVVGIIL GSPSVDNYGQ MHIVNHSSGI NCVLDFKPRG WRGTNAHEVK GSVQSTDDTP 240
  241 KWMVNGHWND KIFGQQPNGN KILLWQNHER PPRPFNLTPF AISLNALTPQ LKPWLPPTDT 300
  301 RLRPDQRAME NGQYDLAASE KNRLEEKQRK KRRMREQGEM PPWSPRWFSA AKHPVTGEDY 360
  361 WQFNNEYWKI REEAGEAHLA GKEFEWPNVD DIF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 80.69897
Match: 1zhtA
Description: Structure of yeast oxysterol binding protein Osh4 in complex with 7-hydroxycholesterol
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
sterol binding 3.12877992228795 bayes_pls_golite062009
steroid binding 2.54679035876403 bayes_pls_golite062009
binding 1.67154210149282 bayes_pls_golite062009
lipid binding 1.46539100663772 bayes_pls_golite062009
oxysterol binding 1.1738554488982 bayes_pls_golite062009
0.35288515581255 bayes_pls_golite062009
phospholipid binding 0.0867097353003303 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle