YRC Public Data Repository - Protein Structure Prediction

Protein:	yak3
Organism:	Schizosaccharomyces pombe
Length:	340 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for yak3.

Description	E-value	Query Range	Subject Range
gi\|66780950, gi\|... - gi\|94986270\|ref\|YP_605634.1\| aldo/keto reductase [Deinococcus geothermalis DSM 11300], gi\|94556551\|g...	355.0	[0..3]	[326..1]
gi\|68513185, gi\|... - gi\|68560654\|ref\|ZP_00599965.1\| Aldo/keto reductase [Rubrobacter xylanophilus DSM 9941], gi\|68513185\|...	352.0	[0..3]	[333..1]
gi\|115365408, gi... - gi\|115377607\|ref\|ZP_01464804.1\| aldo/keto reductase [Stigmatella aurantiaca DW4/3-1], gi\|115365408\|g...	350.0	[0..3]	[333..1]
gi\|85775968, gi\|... - gi\|86159457\|ref\|YP_466242.1\| aldo/keto reductase [Anaeromyxobacter dehalogenans 2CP-C], gi\|85775968\|...	349.0	[0..3]	[332..1]
gi\|148265548, gi... - gi\|88934427\|ref\|ZP_01140070.1\| probable oxidoreductase [Geobacter uraniumreducens Rf4], gi\|88918885\|...	349.0	[0..3]	[333..1]
gi\|50119681, gi\|... - gi\|50119681\|ref\|YP_048848.1\| putative aldo/keto reductase [Pectobacterium atrosepticum SCRI1043], gi...	345.0	[0..3]	[332..1]
gi\|186684841, gi... - gi\|23125522\|ref\|ZP_00107451.1\| COG0667: Predicted oxidoreductases (related to aryl-alcohol dehydroge...	345.0	[0..3]	[326..1]
gi\|7471099 - pir\|\|E75296 aldo/keto reductase - Deinococcus radiodurans (strain R1) gi\|15807252, gi\|... - gi\|6460065\|gb\|AAF11806.1\|AE002058_6 aldo/keto reductase [Deinococcus radiodurans R1], gi\|15807252\|re...	344.0	[0..2]	[326..3]
gi\|68179876, gi\|... - gi\|95929754\|ref\|ZP_01312495.1\| aldo/keto reductase [Desulfuromonas acetoxidans DSM 684], gi\|95134050...	344.0	[0..3]	[333..1]
gi\|37520407, gi\|... - gi\|37520407\|ref\|NP_923784.1\| oxidoreductase [Gloeobacter violaceus PCC 7421], gi\|35211400\|dbj\|BAC887...	342.0	[0..3]	[326..1]

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Predicted Domain #1

Region A:
Residues: [1-340]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIPTRKIGN DTVPAIGFGC MGLHAMYGPS SEEANQAVLT HAADLGCTFW DSSDMYGFGA  60
   61 NEECIGRWFK QTGRRKEIFL ATKFGYEKNP ETGELSLNNE PDYIEKALDL SLKRLGIDCI 120
  121 DLYYVHRFSG ETPIEKIMGA LKKCVEAGKI RYIGLSECSA NTIRRAAAVY PVSAVQVEYS 180
  181 PFSLEIERPE IGVMKACREN NITIVCYAPL GRGFLTGAYK SPDDFPEGDF RRKAPRYQKE 240
  241 NFYKNLELVT KIEKIATANN ITPGQLSLAW LLAQGDDILP IPGTKRVKYL EENFGALKVK 300
  301 LSDATVKEIR EACDNAEVIG ARYPPGAGSK IFMDTPPMPK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	81.522879
Match:	1pz1A
Description:	Structure of NADPH-dependent family 11 aldo-keto reductase AKR11B(holo)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
pyridoxine 4-dehydrogenase activity	3.25535446462297	bayes_pls_golite062009
aldo-keto reductase activity	2.57303336304449	bayes_pls_golite062009
aryl-alcohol dehydrogenase activity	2.5168190536972	bayes_pls_golite062009
catalytic activity	1.68179794468736	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.48881830724998	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.47641884930911	bayes_pls_golite062009
oxidoreductase activity	1.17915737521094	bayes_pls_golite062009
aldehyde reductase activity	1.16639404121425	bayes_pls_golite062009
binding	1.15657176144267	bayes_pls_golite062009
protein binding	0.220529867719707	bayes_pls_golite062009
3-alpha-hydroxysteroid dehydrogenase (B-specific) activity	0.207008954325429	bayes_pls_golite062009
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	0.207008954325429	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: