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View Structure Prediction Details

Protein: ura3
Organism: Schizosaccharomyces pombe
Length: 443 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ura3.

Description E-value Query
Range		 Subject
Range
gi|238878616 - gi|238878616|gb|EEQ42254.1| dihydroorotate dehydrogenase, mitochondrial precursor [Candida albicans ...
PYRD_CANAL - Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-...
PYRD_CANAL - Dihydroorotate dehydrogenase, mitochondrial OS=Candida albicans GN=URA9 PE=1 SV=1
 278.0 [0..2] [443..8]
gi|49073196, gi|... - gi|71018263|ref|XP_759362.1| hypothetical protein UM03215.1 [Ustilago maydis 521], ref|XP_400830.1| ...
 268.0 [0..9] [434..45]
gi|112950051 - gi|112950051|gb|ABI26629.1| dihydroorotate dehydrogenase [Ustilago maydis]
 265.0 [0..9] [434..45]
PYRD_ARATH - Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Arabidopsis thaliana GN=PYRD PE=1 SV=2
 259.0 [0..6] [441..17]
PYRD_RAT - Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Rattus norvegicus GN=Dhodh PE=1 SV=1
gi|4379422 - emb|CAA56765.1| dihydroorotate dehydrogenase [Rattus rattus]
 255.0 [0..32] [441..3]
DHODH - dihydroorotate dehydrogenase
 251.0 [0..31] [442..3]
PYRD_MOUSE - Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Mus musculus GN=Dhodh PE=1 SV=2
 251.0 [0..32] [441..3]
PYRD_PONAB - Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Pongo abelii GN=DHODH PE=2 SV=1
PYRD_PONPY - Dihydroorotate dehydrogenase, mitochondrial precursor - Pongo pygmaeus (Orangutan)
 250.0 [0..32] [442..3]
gi|110665638 - gi|110665638|gb|ABG81465.1| dihydroorotate dehydrogenase precursor [Bos taurus]
 249.0 [0..32] [441..1]
gi|109129102 - gi|109129102|ref|XP_001104448.1| PREDICTED: similar to dihydroorotate dehydrogenase isoform 1 precur...
 249.0 [0..32] [442..3]

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Predicted Domain #1
Region A:
Residues: [1-443] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYQRSLFRGV AQGLKRSSVR FQSTSSGSSN GNFFLRHWKL LSVIGSFTAG VAIYDMSDVR  60
   61 SFIHGRIEMP LFHAFTTPEF SHRVAILAAS WGITPKDRVA DDPSLAVEVW GKKFCNPIGL 120
  121 AAGFDKQADA ISGLLNFGFS YLEIGSVTPK PQPGNPKPRY FRLKPDLSVI NRYGFNSIGH 180
  181 DAILAKIQKR VRKYIAKTSP QLLKQFDANP ASCTDPAVLG VPRSLIPNKF LGINLGKNKN 240
  241 GNEIEDYVEG VRTFGNFADI LVINVSSPNT PGLRNLQKKS ALSTLLTAVV SERNKLNSPH 300
  301 PPVLVKIAPD LNEEELTDIA DVLKKCKIDG VIVGNTTVQR PKTLKSTSHV EETGGLSGPP 360
  361 LKPIALNTLR TLRKHLSSDI PIIGCGGISS GKDAIEYARA GATMVQVYTA LGYDGPVIAH 420
  421 KIKQEILAEL KGKRWVDIIG KEE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 63.09691
Match: 1uumA
Description: Rat dihydroorotate dehydrogenase (DHOD)in complex with atovaquone
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
oxidoreductase activity 2.7385769437489 bayes_pls_golite062009
dihydroorotate dehydrogenase activity 2.73800716363956 bayes_pls_golite062009
dihydroorotate oxidase activity 2.35584458985229 bayes_pls_golite062009
catalytic activity 1.94749091175302 bayes_pls_golite062009
dihydropyrimidine dehydrogenase (NADP+) activity 1.76080169529176 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor 0.962937319088834 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors 0.876786102965635 bayes_pls_golite062009
nucleic acid binding 0.126127705865716 bayes_pls_golite062009
binding 0.100344139383616 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle