YRC Public Data Repository - Protein Structure Prediction

Protein:	SPAC1486.06
Organism:	Schizosaccharomyces pombe
Length:	410 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPAC1486.06.

Description	E-value	Query Range	Subject Range
gi\|94311385, gi\|... - gi\|94311385\|ref\|YP_584595.1\| nicotinate phosphoribosyltransferase [Ralstonia metallidurans CH34], gi...	431.0	[0..5]	[405..9]
gi\|17428044 - gi\|17428044\|emb\|CAD14733.1\| probable nicotinate phosphoribosyltransferase (naprtase) protein [Ralsto... gi\|17545750 - gi\|17545750\|ref\|NP_519152.1\| nicotinate phosphoribosyltransferase [Ralstonia solanacearum GMI1000]	421.0	[0..5]	[407..17]
gi\|91784741, gi\|... - gi\|91784741\|ref\|YP_559947.1\| nicotinate phosphoribosyltransferase [Burkholderia xenovorans LB400], g...	421.0	[0..5]	[408..16]
gi\|67550118, gi\|... - gi\|67550118\|ref\|ZP_00427925.1\| Nicotinate phosphoribosyltransferase [Burkholderia vietnamiensis G4],...	420.0	[0..2]	[408..51]
PNCB_RALSO - Nicotinate phosphoribosyltransferase OS=Ralstonia solanacearum GN=pncB PE=3 SV=2 PNCB_RALSO - Nicotinate phosphoribosyltransferase OS=Ralstonia solanacearum (strain GMI1000) GN=pncB PE=3 SV=2	420.0	[0..5]	[407..2]
gi\|207341031 - gi\|207341031\|gb\|EDZ69202.1\| YOR209Cp-like protein [Saccharomyces cerevisiae AWRI1631] NPT1 - Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for... NPT1_YEAST - Nicotinate phosphoribosyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NPT...	419.0	[0..1]	[407..1]
gi\|110614488, gi... - gi\|110804940\|ref\|YP_688460.1\| nicotinate phosphoribosyltransferase [Shigella flexneri 5 str. 8401], ... gi\|170020667, gi... - gi\|170020667\|ref\|YP_001725621.1\| nicotinate phosphoribosyltransferase [Escherichia coli ATCC 8739], ... gi\|24051204, gi\|... - ref\|NP_706850.1\| nicotinate phosphoribosyltransferase [Shigella flexneri 2a str. 301], gb\|AAN42557.... gi\|124499410, gi... - gi\|124530123\|ref\|ZP_01700893.1\| nicotinate phosphoribosyltransferase [Escherichia coli B], gi\|124499...	418.0	[0..2]	[408..21]
gi\|77966430, gi\|... - gi\|78065685\|ref\|YP_368454.1\| nicotinate phosphoribosyltransferase [Burkholderia sp. 383], gi\|7796643...	418.0	[0..5]	[408..2]
gi\|194438710, gi... - gi\|83585874\|ref\|ZP_00924514.1\| COG1488: Nicotinic acid phosphoribosyltransferase [Escherichia coli 1... gi\|30062466, gi\|... - gi\|30062466\|ref\|NP_836637.1\| nicotinate phosphoribosyltransferase [Shigella flexneri 2a str. 2457T],... PNCB_ECO24 - Nicotinate phosphoribosyltransferase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=pncB PE... gi\|251784473, gi... - gi\|251784473\|ref\|YP_002998777.1\| hypothetical protein B21_00942 [Escherichia coli BL21], gi\|24237674... gi\|254161045, gi... - gi\|254161045\|ref\|YP_003044153.1\| nicotinate phosphoribosyltransferase [Escherichia coli B str. REL60... gi\|253977160, gi... - gi\|254287853\|ref\|YP_003053601.1\| nicotinate phosphoribosyltransferase [Escherichia coli BL21(DE3)], ... PNCB_ECO55 - Nicotinate phosphoribosyltransferase OS=Escherichia coli (strain 55989 / EAEC) GN=pncB PE=3 SV=1 PNCB_ECOSE - Nicotinate phosphoribosyltransferase OS=Escherichia coli (strain SE11) GN=pncB PE=3 SV=1 PNCB_ECO8A - Nicotinate phosphoribosyltransferase OS=Escherichia coli O8 (strain IAI1) GN=pncB PE=3 SV=1 gi\|190903000, gi... - gi\|75229863\|ref\|ZP_00716386.1\| COG1488: Nicotinic acid phosphoribosyltransferase [Escherichia coli B... PNCB_SHISS - Nicotinate phosphoribosyltransferase OS=Shigella sonnei (strain Ss046) GN=pncB PE=3 SV=1 PNCB_ECOHS - Nicotinate phosphoribosyltransferase OS=Escherichia coli O9:H4 (strain HS) GN=pncB PE=3 SV=1 PNCB_SHIFL - Nicotinate phosphoribosyltransferase OS=Shigella flexneri GN=pncB PE=3 SV=4 gi\|75214729, gi\|... - gi\|75214729\|ref\|ZP_00713234.1\| COG1488: Nicotinic acid phosphoribosyltransferase [Escherichia coli E... PNCB_SHIBS - Nicotinate phosphoribosyltransferase OS=Shigella boydii serotype 4 (strain Sb227) GN=pncB PE=3 SV=1 gi\|56383326, gi\|... - gi\|56479775\|ref\|NP_706850.2\| nicotinate phosphoribosyltransferase [Shigella flexneri 2a str. 301], g...	418.0	[0..2]	[408..5]
PNCB_SHIB3 - Nicotinate phosphoribosyltransferase OS=Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) GN=...	418.0	[0..2]	[408..5]

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Predicted Domain #1

Region A:
Residues: [1-410]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEPAVVSIL DTDLYKLTML QAVLEHYPDA QVSYKYTNRS PKMALNQEAY NWLREQIRGL  60
   61 RNLHLLPEEE QWLRKNCPYL KESFYEFMHE FEFDPENSIS LNYDSETKDL SIFIHGLWKN 120
  121 TIFYEIPLLA LVSESYFKFV DKDWSPEGQF EKAYEKGKRL IRAGCAFTDF GTRRRRDPHT 180
  181 QEIVLQGLMK AQEDFKGPGS FLGTSNVYFA AKYNLNVSGT VAHEWYMGIA AITQNYKQAN 240
  241 RIASLKWVQT FGTSLLIALT DTFSTDVFLK SFTANSADDL ANVFHGVRQD SGCAEEYIEK 300
  301 VVKHYKSIGV DPSTKVIVHS DALNVDRCIE LYKYCEKCGI KSAFGIGTNL TSDFQKVSNP 360
  361 SEVSKPMNIV IKLFSAEGTK AVKISDDIMK NTGDRDAVIQ AKHQLCLPIA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	118.0
Match:	1vlpA
Description:	Crystal structure of nicotinate phosphoribosyltransferase (yor209c) from Saccharomyces cerevisiae at 1.75 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nicotinate phosphoribosyltransferase activity	5.75487746784842	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	4.79136593406808	bayes_pls_golite062009
nicotinate-nucleotide diphosphorylase (carboxylating) activity	3.97201856258863	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	3.41342374351311	bayes_pls_golite062009
catalytic activity	2.59603106157451	bayes_pls_golite062009
transferase activity	1.91642626258277	bayes_pls_golite062009
binding	1.73051405037757	bayes_pls_golite062009
protein binding	0.294646489785198	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: