YRC Public Data Repository - Protein Structure Prediction

Protein:	mob2
Organism:	Schizosaccharomyces pombe
Length:	244 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mob2.

Description	E-value	Query Range	Subject Range
gi\|73975379 - gi\|73975379\|ref\|XP_539306.2\| PREDICTED: similar to Mps one binder kinase activator-like 1A (Mob1 hom...	360.0	[0..36]	[243..189]
gi\|10435207 - gi\|10435207\|dbj\|BAB14525.1\| unnamed protein product [Homo sapiens]	356.0	[0..30]	[243..1]
MOL1B_PONPY - Mps one binder kinase activator-like 1B - Pongo pygmaeus (Orangutan) gi\|55606148 - gi\|55606148\|ref\|XP_515735.1\| PREDICTED: Mob4B protein isoform 4 [Pan troglodytes] tr\|G1SUR2\|G1SUR2... - Uncharacterized protein OS=Oryctolagus cuniculus GN=MOB1A PE=4 SV=2 MOB1A_MOUSE - MOB kinase activator 1A OS=Mus musculus GN=Mob1a PE=2 SV=3 MOBKL1B - MOB1, Mps One Binder kinase activator-like 1B (yeast) MOB1A_PONAB - MOB kinase activator 1A OS=Pongo abelii GN=MOB1A PE=2 SV=3 MOB1A_RAT - MOB kinase activator 1A OS=Rattus norvegicus GN=Mob1a PE=2 SV=3 gi\|111305145, gi... - gi\|76628940\|ref\|XP_871266.1\| PREDICTED: similar to Mob4B protein [Bos taurus], gi\|115496426\|ref\|NP_0... gi\|73980517 - gi\|73980517\|ref\|XP_852858.1\| PREDICTED: similar to Mob4B protein isoform 1 [Canis familiaris]	356.0	[0..30]	[243..1]
gi\|115313732, gi... - gi\|89269096\|emb\|CAJ81503.1\| MOB1, Mps One Binder kinase activator-like 1B [Xenopus tropicalis], gi\|6...	354.0	[0..30]	[243..1]
gi\|109484173, gi... - gi\|34856301\|ref\|XP_342714.1\| PREDICTED: similar to Mob4B protein [Rattus norvegicus], gi\|27730897\|re...	354.0	[0..30]	[243..1]
gi\|109103421 - gi\|109103421\|ref\|XP_001107567.1\| PREDICTED: similar to Mob4B protein [Macaca mulatta]	353.0	[0..35]	[243..48]
gi\|47226439 - gi\|47226439\|emb\|CAG08455.1\| unnamed protein product [Tetraodon nigroviridis]	353.0	[0..35]	[243..1]
gi\|50746669 - gi\|50746669\|ref\|XP_420601.1\| PREDICTED: similar to MOB1, Mps One Binder kinase activator-like 1A (ye...	353.0	[0..30]	[243..1]
gi\|66530023 - gi\|66530023\|ref\|XP_393046.2\| PREDICTED: similar to mob as tumor suppressor CG13852-PA [Apis mellifer...	352.0	[0..30]	[242..1]

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Predicted Domain #1

Region A:
Residues: [1-244]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFLLNSLSRI TRGNRSKRHQ NLSDASSSSG SFSKKSSTSQ LVRTGSPSVE PTALYLQQPF  60
   61 VRTHLVKGNF STIVSLPRFV DLDEWVALNV YELFTYLNHF YDVFATFCTV KTCPVMSAAA 120
  121 NFDYTWLDNN RKPVHLPAPQ YIEYVLAWIE NRLHDQNVFP TKAGLPFPSN FLVIVKAIYK 180
  181 QMFRIFAHMY YAHYAEILHL SLEAHWNSFF AHFIAFGKEF QLLDKRDTAP LKDLIVVLEN 240
  241 QGNI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	88.522879
Match:	1pi1A
Description:	Crystal structure of a human Mob1 protein; toward understanding Mob-regulated cell cycle pathways.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.92301852481284	bayes_pls_golite062009
kinase regulator activity	1.89112613830997	bayes_pls_golite062009
enzyme regulator activity	1.85961781963242	bayes_pls_golite062009
protein binding	1.70532605681329	bayes_pls_golite062009
protein kinase regulator activity	1.22656624834768	bayes_pls_golite062009
enzyme activator activity	1.01199608762933	bayes_pls_golite062009
kinase activator activity	0.48120280834988	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: