YRC Public Data Repository - Protein Structure Prediction

Protein:	mad2
Organism:	Schizosaccharomyces pombe
Length:	203 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mad2.

Description	E-value	Query Range	Subject Range
gi\|115390332, gi... - gi\|115390332\|ref\|XP_001212671.1\| mitotic spindle checkpoint component mad2 [Aspergillus terreus NIH2...	279.0	[0..9]	[201..13]
gi\|169780902 - gi\|169780902\|ref\|XP_001824915.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|83773655 - gi\|83773655\|dbj\|BAE63782.1\| unnamed protein product [Aspergillus oryzae]	276.0	[0..1]	[201..1]
gi\|40744840, gi\|... - gi\|67524107\|ref\|XP_660115.1\| hypothetical protein AN2511.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	272.0	[0..9]	[201..14]
gi\|50746731 - gi\|50746731\|ref\|XP_420629.1\| PREDICTED: similar to mitotic feedback control protein Madp2 homolog is...	271.0	[0..1]	[202..1]
mdf-2 - status:Confirmed UniProt:Q9NGT3 protein_id:AAK68576.1	269.0	[0..1]	[202..1]
gi\|73983524 - gi\|73983524\|ref\|XP_533278.2\| PREDICTED: similar to Mitotic spindle assembly checkpoint protein MAD2A...	267.0	[0..1]	[201..1]
gi\|187028294, gi... - gi\|39585923\|emb\|CAE68212.1\| Hypothetical protein CBG13880 [Caenorhabditis briggsae], gi\|187028294\|em... gi\|157759197 - gi\|157759197\|ref\|XP_001671942.1\| Hypothetical protein CBG13880 [Caenorhabditis briggsae AF16]	267.0	[0..1]	[202..1]
gi\|218195086 - gi\|218195086\|gb\|EEC77513.1\| hypothetical protein OsI_16383 [Oryza sativa Indica Group] gi\|215767269, gi... - gi\|215767269\|dbj\|BAG99497.1\| unnamed protein product [Oryza sativa Japonica Group], gi\|115459076\|ref...	267.0	[0..2]	[202..3]
gi\|157819417, gi... - gi\|27711040\|ref\|XP_216161.1\| PREDICTED: similar to Mitotic spindle assembly checkpoint protein MAD2A...	266.0	[0..1]	[200..1]
gi\|60677614 - gi\|60677614\|dbj\|BAD90977.1\| MAD2 [Triticum aestivum]	266.0	[0..2]	[202..3]

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Predicted Domain #1

Region A:
Residues: [1-203]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSVPIRTNF SLKGSSKLVS EFFEYAVNSI LFQRGIYPAE DFKVVRKYGL NMLVSVDEEV  60
   61 KTYIRKIVSQ LHKWMFAKKI QKLILVITSK CSGEDLERWQ FNVEMVDTAD QFQNIGNKED 120
  121 ELRVQKEIQA LIRQITATVT FLPQLEEQCT FNVLVYADKD SEVPTDWVDS DPRILRDAEQ 180
  181 VQLRSFSTSM HKIDCQVAYR VNP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	70.39794
Match:	1s2hA
Description:	The Mad2 spindle checkpoint protein possesses two distinct natively folded states
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.14424444268625	bayes_pls_golite062009
protein binding	0.856075580719879	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: