YRC Public Data Repository - Protein Structure Prediction

Protein:	isp6
Organism:	Schizosaccharomyces pombe
Length:	467 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for isp6.

Description	E-value	Query Range	Subject Range
gi\|40746955, gi\|... - gi\|67515913\|ref\|XP_657842.1\| hypothetical protein AN0238.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	302.0	[0..38]	[466..83]
PRTB_YEAST - Cerevisin OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PRB1 PE=1 SV=1 PRB1 - Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degrad...	299.0	[0..65]	[467..158]
gi\|116193325, gi... - gi\|88182293\|gb\|EAQ89761.1\| hypothetical protein CHGG_06380 [Chaetomium globosum CBS 148.51], gi\|1161...	299.0	[0..43]	[466..3]
gi\|171680111 - gi\|171680111\|ref\|XP_001905001.1\| unnamed protein product [Podospora anserina] gi\|7400480, gi\|1... - gi\|7400480\|gb\|AAC03564.2\| subtilisin-like serine protease [Podospora anserina], gi\|170939682\|emb\|CAP...	298.0	[0..63]	[466..23]
gi\|15808807 - gi\|15808807\|gb\|AAL08510.1\|AF413106_1 subtilase [Ophiostoma piliferum]	296.0	[0..49]	[466..2]
gi\|111182171, gi... - gi\|118498761\|gb\|ABK96987.1\| serine protease p2 [Chaetomium thermophilum], gi\|111182171\|gb\|ABH07518.1...	293.0	[0..61]	[466..21]
ALP2_ASPFC - Alkaline protease 2 OS=Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) GN=alp2 PE=3 SV... gi\|2143220, gi\|5... - gi\|5139328\|emb\|CAB45520.1\| serine proteinase [Aspergillus fumigatus], gi\|2143220\|emb\|CAA73782.1\| cel... ALP2_ASPFU - Alkaline protease 2 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)...	292.0	[0..41]	[466..1]
gi\|6624962 - gi\|6624962\|emb\|CAB63913.1\| subtilisin-like protease PR1H [Metarhizium anisopliae var. anisopliae] gi\|6624962\|emb\|C... - subtilisin-like protease PR1H [Metarhizium anisopliae var. anisopliae]	292.0	[0..41]	[466..1]

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Predicted Domain #1

Region A:
Residues: [1-69]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRIPYSNLFS AAAGLALFAS TACAAPVMPA TDSDIAHAGI RPELDNAFYD SHGEAATPKH  60
   61 KPHAGPNAA

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [70-190]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLLSASNADT TGLDSHYIIV LQPDLSEQEF QAHTNWVSEM HQMDIASQED EYYDTSDSNY  60
   61 MFGLKHVYDF GEDSFKGYSG QFSSNIVEQI RLHPHVIAVE RDQVVSIKKL ETQSGAPWGL 120
  121 A

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	3.69897
Match:	1scjB
Description:	Subtilisin prosegment
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [191-467]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RISHKSVKYD DIGKYVYDSS AGDNITAYVV DTGVSIHHVE FEGRASWGAT IPSGDVDEDN  60
   61 NGHGTHVAGT IASRAYGVAK KAEIVAVKVL RSSGSGTMAD VIAGVEWTVR HHKSSGKKTS 120
  121 VGNMSLGGGN SFVLDMAVDS AVTNGVIYAV AAGNEYDDAC YSSPAASKKA ITVGASTIND 180
  181 QMAYFSNYGS CVDIFAPGLN ILSTWIGSNT STNTISGTSM ATPHVAGLSA YYLGLHPAAS 240
  241 ASEVKDAIIK MGIHDVLLSI PVGSSTINLL AFNGAQE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	47.30103
Match:	1ic6A
Description:	Proteinase K
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	4.68838733699853	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	4.20928698248021	bayes_pls_golite062009
endopeptidase activity	3.45296270246929	bayes_pls_golite062009
hydrolase activity	3.36483239319728	bayes_pls_golite062009
serine hydrolase activity	1.90036575189745	bayes_pls_golite062009
serine-type peptidase activity	1.89198766955068	bayes_pls_golite062009
binding	1.85875472341221	bayes_pls_golite062009
serine-type endopeptidase activity	1.23150012549143	bayes_pls_golite062009
catalytic activity	0.597535457699629	bayes_pls_golite062009
protein binding	0.380935140681308	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: