YRC Public Data Repository - Protein Structure Prediction

Protein:	tif452
Organism:	Schizosaccharomyces pombe
Length:	243 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tif452.

Description	E-value	Query Range	Subject Range
gi\|50746789 - gi\|50746789\|ref\|XP_420655.1\| PREDICTED: similar to eIF-4E [Gallus gallus]	295.0	[0..24]	[243..55]
gi\|67969074 - gi\|67969074\|dbj\|BAE00892.1\| unnamed protein product [Macaca fascicularis]	287.0	[0..48]	[243..44]
gi\|94370433 - gi\|94370433\|ref\|XP_930840.2\| PREDICTED: similar to eIF-4E [Mus musculus]	287.0	[0..44]	[243..17]
IF4E_MOUSE - Eukaryotic translation initiation factor 4E OS=Mus musculus GN=Eif4e PE=1 SV=1 IF4E_RAT - Eukaryotic translation initiation factor 4E OS=Rattus norvegicus GN=Eif4e PE=1 SV=1	287.0	[0..44]	[243..17]
IF4E_RABIT - Eukaryotic translation initiation factor 4E OS=Oryctolagus cuniculus GN=EIF4E PE=1 SV=1	285.0	[0..48]	[243..21]
gi\|60830630 - gi\|60830630\|gb\|AAX36938.1\| eukaryotic translation initiation factor 4E [synthetic construct]	285.0	[0..48]	[243..21]
gi\|147904808, gi... - gi\|7443509\|pir\|\|S69004 translation initiation factor eIF-4E, long splice form - African clawed frog,...	285.0	[0..18]	[243..12]
gi\|71041838 - gi\|71041838\|pdb\|1WKW\|A Chain A, Crystal Structure Of The Ternary Complex Of Eif4e-M7gpppa- 4ebp1 Pep...	285.0	[0..56]	[243..3]
gi\|74001995 - gi\|74001995\|ref\|XP_544992.2\| PREDICTED: similar to Eukaryotic translation initiation factor 4E (eIF4...	285.0	[0..48]	[243..21]

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Predicted Domain #1

Region A:
Residues: [1-243]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADAEDSRHS KNEGFPNTSL ITEKLDLLDL FGSPKVKTER EGRPARLLEG LSAVNAETAF  60
   61 VKTHPLQHEW TLWFLKPPTQ GLEWSDLLKE IISFKTVEEF WGIFKTISKA SMLPAKSDYS 120
  121 YFLKGIRPEW EDPQNMNGGK WAYQSKHKGS NLDELWLYMV LAAIGETLDP TGKEVTGVVC 180
  181 NMRKGFYRIA VWTRNCNDKD VLEKIGLRFK EVLGISDKET IEYSAHEDSS KAGSMRAKTR 240
  241 MSL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	59.522879
Match:	1rf8A
Description:	Solution structure of the yeast translation initiation factor eIF4E in complex with m7GDP and eIF4GI residues 393 to 490
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
translation initiation factor activity	12.6022960879923	bayes_pls_golite062009
RNA cap binding	8.70938037002519	bayes_pls_golite062009
translation factor activity, nucleic acid binding	7.91586572659635	bayes_pls_golite062009
translation regulator activity	7.87578736455963	bayes_pls_golite062009
RNA binding	4.72356710460779	bayes_pls_golite062009
nucleic acid binding	2.59281897417644	bayes_pls_golite062009
binding	2.24798267677087	bayes_pls_golite062009
protein binding	0.873044754151905	bayes_pls_golite062009
RNA 7-methylguanosine cap binding	0.544036568660606	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: