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View Structure Prediction Details

Protein: tif32
Organism: Schizosaccharomyces pombe
Length: 932 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tif32.

Description E-value Query
Range
Subject
Range
MYH4_PIG - Myosin-4 OS=Sus scrofa GN=MYH4 PE=2 SV=1
364.0 [0..7] [932..996]
MYH4_RAT - Myosin-4 OS=Rattus norvegicus GN=Myh4 PE=1 SV=1
363.0 [0..7] [932..998]
MYH4_MOUSE - Myosin-4 OS=Mus musculus GN=Myh4 PE=2 SV=1
363.0 [0..7] [932..998]
MYH4_RABIT - Myosin-4 OS=Oryctolagus cuniculus GN=MYH4 PE=1 SV=1
363.0 [0..7] [932..997]
MYH4_CANLF - Myosin-4 OS=Canis lupus familiaris GN=MYH4 PE=3 SV=1
363.0 [0..7] [932..998]
MYH1_BOVIN - Myosin-1 OS=Bos taurus GN=MYH1 PE=2 SV=2
362.0 [0..7] [932..997]
gi|109113271 - gi|109113271|ref|XP_001113877.1| PREDICTED: myosin, heavy polypeptide 2, skeletal muscle, adult [Mac...
362.0 [0..7] [932..998]

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Predicted Domain #1
Region A:
Residues: [1-201]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPPQGKPEN VLRLADELIA LDQHSSALQS LHETIVLKRS RNAQGFSLEP IMMRFIELCV  60
   61 HLRKGKIAKE GLYTYKNAVQ NTSVTAIENV VKHFIELANK RVQEAQEKAD KISVEYVDDL 120
  121 EATETPESIM MSLVSGDLSK SRTDRALVTP WLKFLWDAYR TVLDILRNNA RLEVMYQLIA 180
  181 NSAFQFCLKY QRKTEFRRLC E

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [202-324]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLRSHLGNAS KFSNAPHSIN LNDAETMQRH LDMRFSQLNV AVELELWQEA FRSIEDIHSL  60
   61 LTFSKRAPAA VMLGNYYRKL IKIFLVCDNY LLHAAAWNRY FTFTNVQKPA TANFVILSAL 120
  121 SIP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.750 0.823 translation initiation factor activity a.118.1 ARM repeat

Predicted Domain #3
Region A:
Residues: [325-413]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IIDANKLSGP SIEAEDAKSK NARLALLLNL SKTPTRETLI KDAISRGVLS FCDQAIRDLY  60
   61 QILEVEFHPL SICKKLQPII KRLAESNDT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [414-538]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AQYIRPLQQV ILTRLFQQLS QVYDSISLKY VMDLATFEEP YDFNPGQIEK FIMNGNKKGA  60
   61 FSIRLNHIEN SISFSSDLFS NPIKSSDSVS LQSTPSELIT SQLTRIAKSL SSVLMRFDTD 120
  121 FCLLR

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.1
Match: 1ufmA
Description: Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.79393646713264 bayes_pls_golite062009
DNA binding 3.49224482622525 bayes_pls_golite062009
nucleic acid binding 3.44526829828119 bayes_pls_golite062009
structural constituent of ribosome 2.974370828939 bayes_pls_golite062009
transcription factor activity 2.7749459098618 bayes_pls_golite062009
binding 2.73671056234733 bayes_pls_golite062009
structural molecule activity 2.72616711594099 bayes_pls_golite062009
sequence-specific DNA binding 1.22614366856306 bayes_pls_golite062009
transcription activator activity 1.09150217878747 bayes_pls_golite062009
transcription repressor activity 1.00086155936348 bayes_pls_golite062009
protein binding 0.726445167461826 bayes_pls_golite062009
RNA binding 0.352569950847387 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.294869091673654 bayes_pls_golite062009
mRNA binding 0.262190946714123 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [539-932]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQQAEAAYER AQAGVEQERK AVIAQRSLLE LRRGQADTLA TQREAELAAQ RALKQKQESE  60
   61 AESLRVQEEI NKRNAERIRR EKEAIRINEA KKLAEELKAK GGLEVNAEDL EHLDADKLRA 120
  121 MQIEQVEKQN KSMNERLRVI GKRIDHLERA YRREAIPLWE EDAKQQAEHD REIFYEREKQ 180
  181 RKEVQERKHE QAIKDKKAFA QFASYIHAYK QNIDDERDKA YQEAYAKAKN VIDAERERQR 240
  241 KEIFEQKLAE AIREAEEEAA RAAEEEANRE LHEQEEAQKR AIEERTRAAR EAKEREQREM 300
  301 AEKLERQRRI QQERDEEISR KLAEKAAARR ANIGASSPSP GAWRRGGASA GGVSRDSPRY 360
  361 SRGGYSRGSV PPRETLAPSK GAYVPPSRRN QQQQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.69897
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle