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View Structure Prediction Details

Protein: tif35
Organism: Schizosaccharomyces pombe
Length: 282 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tif35.

Description E-value Query
Range
Subject
Range
gi|50938775, gi|... - gi|50938775|ref|XP_478915.1| putative heterogeneous nuclear ribonucleoprotein A1 [Oryza sativa (japo...
176.0 [0..97] [282..1]
gi|114674409 - gi|114674409|ref|XP_001147948.1| PREDICTED: similar to DAZ associated protein 1 isoform 1 [Pan trogl...
174.0 [0..97] [282..30]
gi|40738468, gi|... - gi|67539694|ref|XP_663621.1| hypothetical protein AN6017.2 [Aspergillus nidulans FGSC A4], ref|XP_41...
171.0 [0..1] [280..497]
gi|25470890, gi|... - gi|25470890|ref|NP_733829.1| DAZ associated protein 1 isoform a [Homo sapiens], gi|119589909|gb|EAW6...
170.0 [0..102] [282..10]
gi|70989777, gi|... - gi|70989777|ref|XP_749738.1| heterogeneous nuclear ribonucleoprotein HRP1 [Aspergillus fumigatus Af2...
169.0 [0..11] [281..12]
gi|53127644, gi|... - gi|71894833|ref|NP_001026599.1| DAZ associated protein 1 [Gallus gallus], gi|53127644|emb|CAG31151.1...
169.0 [0..102] [282..11]
gi|89271354 - gi|89271354|emb|CAJ83458.1| DAZ associated protein 1 [Xenopus tropicalis]
168.0 [0..102] [282..10]

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Predicted Domain #1
Region A:
Residues: [1-90]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSSKSLDWA DDEDYGTGLP SIQTFDNPDG TKTMIEFRID DNGKKVKVTR VIRKTVITER  60
   61 VQHAVAERKK WKKFGKEAGK NSGVDARTTS 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.626 d.93.1 SH2 domain
View Download 0.617 d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.672 b.40.2 Bacterial enterotoxins
View Download 0.626 d.93.1 SH2 domain
View Download 0.619 d.93.1 SH2 domain

Predicted Domain #2
Region A:
Residues: [91-282]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGENVQLRLQ LGWTTTKEEE QDEAALAAAK VKAKGSSVVR CRACKGNHFT AQCPYKSIIG  60
   61 PVDEPPLDAS PVSSRASGAL GEKGRYIAPH LRAGSGRESG DSMFKRERDD SATLRVTNLS 120
  121 DDTREEELRD LFRRFGGIQR VYLAKDKETG RAKGFAFVSY YDRDCAIKAR DRLDGYGWNN 180
  181 LILRCEFSKP RD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.221849
Match: 1ha1A
Description: HNRNP A1 (RBD1,2) FROM HOMO SAPIENS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.50438526063124 bayes_pls_golite062009
nucleic acid binding 3.90076005245206 bayes_pls_golite062009
binding 3.49612884560266 bayes_pls_golite062009
translation initiation factor activity 3.27900316559423 bayes_pls_golite062009
mRNA binding 2.92795844574986 bayes_pls_golite062009
structural molecule activity 2.78501986457503 bayes_pls_golite062009
1.49431666307335 bayes_pls_golite062009
protein binding 1.32954276279597 bayes_pls_golite062009
single-stranded RNA binding 0.90573796517364 bayes_pls_golite062009
RNA cap binding 0.847034036194541 bayes_pls_golite062009
transcription regulator activity 0.837097200210041 bayes_pls_golite062009
DNA binding 0.828908978889027 bayes_pls_golite062009
translation regulator activity 0.38120065819101 bayes_pls_golite062009
poly-pyrimidine tract binding 0.32812362201346 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.128616879457381 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle