YRC Public Data Repository - Protein Structure Prediction

Protein:	tif211
Organism:	Schizosaccharomyces pombe
Length:	306 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tif211.

Description	E-value	Query Range	Subject Range
gi\|39975863, gi\|... - gi\|39975863\|ref\|XP_369322.1\| hypothetical protein MG06142.4 [Magnaporthe grisea 70-15], gb\|EAA53014....	316.0	[0..1]	[304..1]
gi\|28923489, gi\|... - gi\|32417010\|ref\|XP_328983.1\| hypothetical protein [Neurospora crassa], gi\|28923489\|gb\|EAA32669.1\| eu... gi\|85105173 - gi\|85105173\|ref\|XP_961905.1\| eukaryotic translation initiation factor 2 alpha subunit [Neurospora cr...	297.0	[0..1]	[304..1]
gi\|40744551, gi\|... - gi\|67525397\|ref\|XP_660760.1\| hypothetical protein AN3156.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	295.0	[0..1]	[304..1]
gi\|61371853, gi\|... - gi\|61371853\|gb\|AAX43743.1\| eukaryotic translation initiation factor 2 subunit 1 alpha [synthetic con...	289.0	[0..1]	[302..1]
IF2A_XENLA - Eukaryotic translation initiation factor 2 subunit 1 OS=Xenopus laevis GN=eif2s1 PE=2 SV=1	289.0	[0..1]	[302..1]
gi\|47224559 - gi\|47224559\|emb\|CAG03543.1\| unnamed protein product [Tetraodon nigroviridis]	289.0	[0..1]	[302..1]
IF2A_XENTR - Eukaryotic translation initiation factor 2 subunit 1 OS=Xenopus tropicalis GN=eif2s1 PE=2 SV=1	289.0	[0..1]	[302..1]
gi\|114653567, gi... - gi\|55640927\|ref\|XP_510016.1\| PREDICTED: eukaryotic translation initiation factor 2, subunit 1 alpha,... gi\|109084000, gi... - gi\|109084000\|ref\|XP_001106000.1\| PREDICTED: eukaryotic translation initiation factor 2, subunit 1 al... gi\|123982672, gi... - gi\|123997343\|gb\|ABM86273.1\| eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa [synt... gi\|90080586 - gi\|90080586\|dbj\|BAE89774.1\| unnamed protein product [Macaca fascicularis] EIF2S1 - eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	289.0	[0..1]	[302..1]
tr\|G1T2G4\|G1T2G4... - pep:known chromosome:oryCun2:20:4901008:4927649:-1 gene:ENSOCUG00000012023 transcript:ENSOCUT0000001... gi\|194038445, gi... - gi\|194038445\|ref\|XP_001928374.1\| PREDICTED: similar to eukaryotic translation initiation factor 2, s... IF2A_MOUSE - Eukaryotic translation initiation factor 2 subunit 1 OS=Mus musculus GN=Eif2s1 PE=1 SV=3 IF2A_BOVIN - Eukaryotic translation initiation factor 2 subunit 1 OS=Bos taurus GN=EIF2S1 PE=2 SV=2 IF2A_RAT - Eukaryotic translation initiation factor 2 subunit 1 OS=Rattus norvegicus GN=Eif2s1 PE=1 SV=2 gi\|57090227 - gi\|57090227\|ref\|XP_537485.1\| PREDICTED: similar to Eukaryotic translation initiation factor 2 subuni...	288.0	[0..1]	[302..1]
gi\|157423429, gi... - gi\|7739753\|gb\|AAF68997.1\|AF257517_1 eIF2 alpha subunit [Danio rerio], gi\|41351478\|gb\|AAH65879.1\| Euk...	288.0	[0..1]	[302..1]

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Predicted Domain #1

Region A:
Residues: [1-306]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTTSCRMYE NRFPEVDELV VVNVRQIQEM GAYVKLLEYD NIEGMVLLSE LSRRRIRSVQ  60
   61 KHIRVGRNEV VVVLRVDKEK GYIDLSKRRV SPEDVVKCEE RFNKSKAVHS IMRHIAEKHN 120
  121 VPLETMYTTI GWPLYRKYGH AYDAFKLAIS NPDHVFEGLE PPKSGVINDL LAQISRRLTP 180
  181 QPIKIRADVE VTCFGYEGIN AIKAALKAAE DVHTEEVPIK VKLVAPPLYV LLTNALDKSL 240
  241 GLKKLEEAIG AIEKSITASN GTCTVKMKPK AVSETDELEL ADLMKKFEKE NAEISGDEED 300
  301 DQSGSE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	76.69897
Match:	1q8kA
Description:	Solution structure of alpha subunit of human eIF2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
translation initiation factor activity	10.6089165352091	bayes_pls_golite062009
structural constituent of ribosome	6.60650180781768	bayes_pls_golite062009
translation regulator activity	6.15562485158748	bayes_pls_golite062009
structural molecule activity	6.0174879876147	bayes_pls_golite062009
DNA binding	3.38561002225202	bayes_pls_golite062009
nucleic acid binding	2.60981339834849	bayes_pls_golite062009
structure-specific DNA binding	2.50756546575713	bayes_pls_golite062009
single-stranded DNA binding	2.36609416429058	bayes_pls_golite062009
binding	2.263388192549	bayes_pls_golite062009
RNA binding	1.76502371106766	bayes_pls_golite062009
transcription regulator activity	1.69669059514663	bayes_pls_golite062009
translation factor activity, nucleic acid binding	1.60662288414996	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.33094846641297	bayes_pls_golite062009
transferase activity	0.945564658432858	bayes_pls_golite062009
mRNA binding	0.883475899526061	bayes_pls_golite062009
transcription factor activity	0.859071050218437	bayes_pls_golite062009
sequence-specific DNA binding	0.77755643935497	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	0.474251377131502	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	0.47336621289748	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	0.47336621289748	bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters	0.448368263932591	bayes_pls_golite062009
exoribonuclease activity	0.40142383001471	bayes_pls_golite062009
3'-5' exonuclease activity	0.33985916978927	bayes_pls_golite062009
3'-5'-exoribonuclease activity	0.16147560902991	bayes_pls_golite062009
protein binding	0.152645195799531	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: