YRC Public Data Repository - Protein Structure Prediction

Protein:	ups1
Organism:	Schizosaccharomyces pombe
Length:	251 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ups1.

Description	E-value	Query Range	Subject Range
gi\|94730811, gi\|... - gi\|94986562\|ref\|YP_594495.1\| siroheme synthase [Lawsonia intracellularis PHE/MN1-00], gi\|94730811\|em...	220.0	[0..2]	[247..253]
gi\|46579147, gi\|... - gi\|46579147\|ref\|YP_009955.1\| uroporphyrinogen III synthase/methyltransferase [Desulfovibrio vulgaris... gi\|241879973, gi... - gi\|241907550\|ref\|ZP_04792127.1\| uroporphyrin-III C-methyltransferase [Desulfovibrio vulgaris RCH1], ... gi\|120603279, gi... - gi\|120603279\|ref\|YP_967679.1\| uroporphyrin-III C-methyltransferase [Desulfovibrio vulgaris subsp. vu...	219.0	[0..2]	[248..252]
gi\|71489436, gi\|... - gi\|71544542\|ref\|ZP_00665566.1\| Uroporphyrin-III C-methyltransferase, C-terminal [Syntrophobacter fum...	219.0	[0..2]	[247..254]
gi\|147677308, gi... - gi\|98661630\|dbj\|GAA01338.1\| unnamed protein product [Pelotomaculum thermopropionicum SI], gi\|1476773...	218.0	[0..2]	[245..255]
gi\|23473894, gi\|... - gi\|78357878\|ref\|YP_389327.1\| uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferas...	218.0	[0..2]	[246..252]
gi\|25315418 - pir\|\|AC2237 uroporphyrinogen III methylase [imported] - Nostoc sp. (strain PCC 7120) gi\|17230942, gi\|... - gi\|17230942\|ref\|NP_487490.1\| uroporphyrinogen III methylase [Nostoc sp. PCC 7120], gi\|17132583\|dbj\|B...	215.0	[0..2]	[245..262]
gi\|48845542, gi\|... - gi\|78224426\|ref\|YP_386173.1\| uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferas...	215.0	[0..2]	[250..260]
gi\|85858419, gi\|... - gi\|85858419\|ref\|YP_460621.1\| uroporphyrin-III C-methyltransferase / uroporphyrinogen-III synthase [S...	215.0	[0..2]	[250..262]
gi\|12655814 - gi\|12655814\|gb\|AAK00606.1\|AF221100_3 uroporphyrinogen III synthase/methyltransferase [Selenomonas ru...	214.0	[0..2]	[244..260]
gi\|108766042, gi... - gi\|108804799\|ref\|YP_644736.1\| uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III syntha...	214.0	[0..2]	[243..253]

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Predicted Domain #1

Region A:
Residues: [1-251]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKTALLLKTK SQPFDPYVEA FEKYGRDTAF IPVLRHKRVH EEQLRDKLKN VRKTYCGLIV  60
   61 TSQRVSETLD EALKQEDETE RQKILMETPI FTVGPATDDS IRRLGFQQTH GKDCGRGEVL 120
  121 ADLIEEWYTT TKQHKPLLFL VGEKHRDIIQ RKLGDDRVDS LIVYATQELE NTETQIKDTI 180
  181 RKHPTIDWIV AFSPTSICSL LNTFELKIAT IGPTTGDYLK KLGTQPNVVS PAPNPESLAS 240
  241 SIVAFDEENS S

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	44.154902
Match:	1jr2A
Description:	Uroporphyrinogen III synthase (U3S, HemD)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
uroporphyrinogen-III synthase activity	3.75954315324218	bayes_pls_golite062009
binding	1.39689732651231	bayes_pls_golite062009
catalytic activity	1.13824203225664	bayes_pls_golite062009
hydro-lyase activity	0.290711782955013	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: