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View Structure Prediction Details

Protein: csx2
Organism: Schizosaccharomyces pombe
Length: 870 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for csx2.

Description E-value Query
Range
Subject
Range
gi|11359444 - gi|11359444|pir||T49496 hypothetical protein B14D6.480 [imported] - Neurospora crassa
407.0 [0..21] [855..63]
gi|49093900, gi|... - gi|67528136|ref|XP_661878.1| hypothetical protein AN4274.2 [Aspergillus nidulans FGSC A4], ref|XP_40...
367.0 [0..12] [846..21]
gi|39951909, gi|... - gi|39951909|ref|XP_363671.1| hypothetical protein MG01597.4 [Magnaporthe grisea 70-15], gb|EAA55946....
355.0 [0..12] [472..165]
gi|115389080, gi... - gi|115389080|ref|XP_001212045.1| hypothetical protein ATEG_02867 [Aspergillus terreus NIH2624], gi|1...
353.0 [0..12] [855..21]
gi|66846759, gi|... - gi|70987431|ref|XP_749129.1| ARF GTPase activator (Csx2) [Aspergillus fumigatus Af293], gi|66846759|...
347.0 [0..12] [855..21]
gi|90299102, gi|... - gi|90299102|gb|EAS28733.1| hypothetical protein CIMG_07479 [Coccidioides immitis RS], gi|119176921|r...
338.0 [0..12] [855..21]
gi|46125485, gi|... - gi|46125485|ref|XP_387296.1| hypothetical protein FG07120.1 [Gibberella zeae PH-1], gi|42554089|gb|E...
333.0 [0..12] [472..21]
gi|116181676, gi... - gi|88185763|gb|EAQ93231.1| hypothetical protein CHGG_01466 [Chaetomium globosum CBS 148.51], gi|1161...
312.0 [0..12] [481..21]
gi|111067443 - gi|111067443|gb|EAT88563.1| hypothetical protein SNOG_03358 [Phaeosphaeria nodorum SN15]
286.0 [0..12] [481..21]
SPAC26A3.10 - Arf GAP protein
CNT6_SCHPO - Probable ribosylation factor GTPase-activating protein cnt6 OS=Schizosaccharomyces pombe (strain 972...
268.0 [0..44] [843..34]

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Predicted Domain #1
Region A:
Residues: [1-189]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTGHVDPVHF ERLKIQSVTF GSANDNASLQ VHNVSKSPEY SKYSYSRKNN EPIEFIQLRE  60
   61 EEGPIVKVEE EDGLTLRFQL EFHAQEGKRD VTNLTCVYGT SPQQLDRLIT REFSSDANFQ 120
  121 NNHQVFLIGN IEFHSNENSK KIEWTWSNQS LHTLYFRNGG SPIYLCFAEY DKRLNCLVPL 180
  181 KTFQFYVTE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.69897
Match: 1u5qA
Description: Crystal Structure of the TAO2 Kinase Domain: Activation and Specifity of a Ste20p MAP3K
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [190-234]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDQDSTPATP FPMPMHLAEE TATSPEISDA PPLSGNVDPL PINSP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.09691
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [235-612]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PLTNPVARDI DQTEPEDGPL FRATILNYER TTHDMRMVLK KLIKRIEHVA HSHGLLYMSY  60
   61 KELMSAFERV ATINPPAFKP FLDHYYAAAA QSFDSFNIDR ARLLRNFLIE PLRKIYDTDI 120
  121 KNVSTKKKDF EETSRDYYTS LSRYLSKSEK ETSSDKTKES KFAAKKRDFE LSRFDYYSYM 180
  181 QDINGGRKGQ EVLSVLTSFA ANDYNLIHSS LTDIDALRPS IIQLQDIVTE ANKEFQLLRA 240
  241 EREERRRYIE TSSRELEDKD AEIAAQAYKA KVDQDTSAKQ GLLLAFSKST SDLQVVGKSG 300
  301 WHKYWVVLDH GKICEYANWK QSLELHTEPI DLLMATVRPA QSVSRKFCFE VITPQTKRTY 360
  361 QATSKAEMHS WIEAIQYS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.69897
Match: 2elbA
Description: No description for 2elbA was found.

Predicted functions:

Term Confidence Notes
binding 2.65091781683225 bayes_pls_golite062009
protein binding 2.12168271674167 bayes_pls_golite062009
GTPase regulator activity 1.66986263418539 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 1.64990514605397 bayes_pls_golite062009
molecular transducer activity 1.55319485371003 bayes_pls_golite062009
signal transducer activity 1.55319485371003 bayes_pls_golite062009
transporter activity 1.28986800087234 bayes_pls_golite062009
small GTPase regulator activity 1.2550809703725 bayes_pls_golite062009
enzyme regulator activity 1.25381967078645 bayes_pls_golite062009
enzyme binding 1.17212675145623 bayes_pls_golite062009
phospholipid binding 1.09683218092034 bayes_pls_golite062009
protein domain specific binding 0.90578029954417 bayes_pls_golite062009
small GTPase binding 0.8507658747425 bayes_pls_golite062009
GTPase binding 0.82889812790119 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.745321902095093 bayes_pls_golite062009
phosphoinositide binding 0.71817045430443 bayes_pls_golite062009
substrate-specific transporter activity 0.54401901869178 bayes_pls_golite062009
receptor binding 0.50127063593663 bayes_pls_golite062009
kinase binding 0.39940885913863 bayes_pls_golite062009
receptor activity 0.353510125274044 bayes_pls_golite062009
transmembrane receptor activity 0.207829786337892 bayes_pls_golite062009
lipid binding 0.179561240451969 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase signaling protein activity 0.13700176999256 bayes_pls_golite062009
receptor signaling protein activity 0.10105990547756 bayes_pls_golite062009
protein kinase binding 0.0918356351234999 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [613-870]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISESIVQKGK GTSMNSEETS VKHGPTSTIG KALQRVASVT SPSRHNSDSK EKKQTKSPSL  60
   61 VKTLKEMHSS DQSCADCNTT ARVEWCAINF PVVLCIDCSG IHRSLGTHIT KIRSLTLDKF 120
  121 NPETVDLLYA TGNSFVNEIY EGGITDWKIK NFENQERRVQ FVKDKYLYKR FIKSSFSHDP 180
  181 NTGLLESIEH SNLKEAVLCL ALGADVNYQR AVVKALLKNN YLIAELLTLN GASLNVDEVT 240
  241 METLSARAQA FVMNRATP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.0
Match: 1dcqA
Description: Pyk2-associated protein beta; Pyk2-associated protein beta ARF-GAP domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle