YRC Public Data Repository - Protein Structure Prediction

Protein:	cgs2
Organism:	Schizosaccharomyces pombe
Length:	346 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cgs2.

Description	E-value	Query Range	Subject Range
CPDP_YERPE - Probable 3',5'-cyclic-nucleotide phosphodiesterase OS=Yersinia pestis GN=cpdP PE=3 SV=1 gi\|149365411, gi... - gi\|149365411\|ref\|ZP_01887446.1\| putative 3',5'-cyclic-nucleotide phosphodiesterase [Yersinia pestis ... gi\|16122901, gi\|... - gi\|218929769\|ref\|YP_002347644.1\| putative 3',5'-cyclic-nucleotide phosphodiesterase [Yersinia pestis...	166.0	[0..3]	[346..9]
gi\|152962077, gi... - gi\|77629947\|ref\|ZP_00792533.1\| COG5212: Low-affinity cAMP phosphodiesterase [Yersinia pseudotubercul...	166.0	[0..3]	[346..11]
Q667S9\|Q667S9_YERPS - Putative 3',5'-cyclic-nucleotide phosphodiesterase precursor - Yersinia pseudotuberculosis gi\|21958034, gi\|... - gi\|22125171\|ref\|NP_668594.1\| hypothetical protein y1271 [Yersinia pestis KIM], gi\|21958034\|gb\|AAM848... gi\|167469000 - gi\|167469000\|ref\|ZP_02333704.1\| 3',5'-cyclic-nucleotide phosphodiesterase [Yersinia pestis FV-1] gi\|229681524, gi... - gi\|229901595\|ref\|ZP_04516717.1\| putative 3',5'-cyclic-nucleotide phosphodiesterase [Yersinia pestis ... gi\|169749944, gi... - gi\|170023410\|ref\|YP_001719915.1\| cyclic-AMP phosphodiesterase [Yersinia pseudotuberculosis YPIII], g... gi\|108808421, gi... - gi\|108808421\|ref\|YP_652337.1\| putative 3',5'-cyclic-nucleotide phosphodiesterase [Yersinia pestis An... gi\|186896328, gi... - gi\|186896328\|ref\|YP_001873440.1\| cyclic-AMP phosphodiesterase [Yersinia pseudotuberculosis PB1/+], g... gi\|89104179, gi\|... - gi\|89104179\|ref\|ZP_01176730.1\| COG5212: Low-affinity cAMP phosphodiesterase [Yersinia pestis biovar ... gi\|229688369, gi... - gi\|229898821\|ref\|ZP_04513966.1\| putative 3',5'-cyclic-nucleotide phosphodiesterase [Yersinia pestis ... gi\|229701355, gi... - gi\|229895549\|ref\|ZP_04510720.1\| putative 3',5'-cyclic-nucleotide phosphodiesterase [Yersinia pestis ... gi\|229694623, gi... - gi\|229838257\|ref\|ZP_04458416.1\| putative 3',5'-cyclic-nucleotide phosphodiesterase [Yersinia pestis ... gi\|165925188, gi... - gi\|165925188\|ref\|ZP_02221020.1\| 3',5'-cyclic-nucleotide phosphodiesterase [Yersinia pestis biovar Or... gi\|166008399, gi... - gi\|166008399\|ref\|ZP_02229297.1\| 3',5'-cyclic-nucleotide phosphodiesterase [Yersinia pestis biovar An... gi\|166212613, gi... - gi\|166212613\|ref\|ZP_02238648.1\| 3',5'-cyclic-nucleotide phosphodiesterase [Yersinia pestis biovar An... gi\|167399328, gi... - gi\|167399328\|ref\|ZP_02304852.1\| 3',5'-cyclic-nucleotide phosphodiesterase [Yersinia pestis biovar An... gi\|51597228, gi\|... - gi\|51597228\|ref\|YP_071419.1\| putative 3',5'-cyclic-nucleotide phosphodiesterase [Yersinia pseudotube... gi\|167421148, gi... - gi\|167421148\|ref\|ZP_02312901.1\| 3',5'-cyclic-nucleotide phosphodiesterase [Yersinia pestis biovar Or... gi\|45437147, gi\|... - gi\|45442283\|ref\|NP_993822.1\| hypothetical protein YP_2500 [Yersinia pestis biovar Microtus str. 9100... gi\|167423309, gi... - gi\|167423309\|ref\|ZP_02315062.1\| 3',5'-cyclic-nucleotide phosphodiesterase [Yersinia pestis biovar Me... gi\|145598859, gi... - gi\|145598859\|ref\|YP_001162935.1\| 3',5'-cyclic-nucleotide phosphodiesterase [Yersinia pestis Pestoide...	166.0	[0..3]	[346..11]
gi\|186463873, gi... - gi\|23125253\|ref\|ZP_00107194.1\| COG1235: Metal-dependent hydrolases of the beta-lactamase superfamily...	163.0	[0..22]	[345..5]
gi\|162418847, gi... - gi\|77634996\|ref\|ZP_00797086.1\| COG5212: Low-affinity cAMP phosphodiesterase [Yersinia pestis Angola]...	162.0	[0..3]	[346..11]
gi\|77978029 - gi\|77978029\|ref\|ZP_00833464.1\| COG5212: Low-affinity cAMP phosphodiesterase [Yersinia intermedia ATC...	160.0	[0..17]	[346..14]
RNZ_METMA - Ribonuclease Z OS=Methanosarcina mazei GN=rnz PE=3 SV=1 RNZ_METMA - Ribonuclease Z OS=Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OC...	160.0	[0..25]	[345..2]
gi\|75702063, gi\|... - gi\|75908338\|ref\|YP_322634.1\| Beta-lactamase-like [Anabaena variabilis ATCC 29413], gi\|75702063\|gb\|AB...	159.0	[0..22]	[345..5]
gi\|77961527, gi\|... - gi\|77961527\|ref\|ZP_00825362.1\| COG5212: Low-affinity cAMP phosphodiesterase [Yersinia mollaretii ATC...	159.0	[0..17]	[346..23]
gi\|59711863, gi\|... - gi\|59711863\|ref\|YP_204639.1\| 3',5'-cyclic-nucleotide phosphodiesterase [Vibrio fischeri ES114], gi\|5...	157.0	[0..22]	[346..22]

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Predicted Domain #1

Region A:
Residues: [1-346]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHAALEIKEA EFQTDQVVGL VENSFTLYSL GQNGGPLESC CSSHLISDGA FQEIISLDGG  60
   61 SHLSALVELI QSKHLSVDSW SSITKYDNYT VENESYAKAW HLSEQRIKTF LITHCHLDHI 120
  121 YGAVINSAMF GPQNPRTIVG LNYVIDTLKK HVFNNLLWPS LDKAGFINFQ VVEPSMYTSL 180
  181 TTTLSILPFP VNHGSSFGQE LKSSAFLFRN NLSDRYFLAF GDVEPDMVAS EPLNIHIWRA 240
  241 CSSLIAQRKL SHILIECSTP DIPDTLLFGH FCPRHLVNEL CILQSLVQSY GVIMPTLTCL 300
  301 LTHLKSHPLQ SANPADVILE QLESLSSKSS LSVTFKILQR GQFYKF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.09691
Match:	1y44A
Description:	Crystal structure of RNase Z
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleic acid binding	2.08234598427969	bayes_pls_golite062009
binding	1.45486959337001	bayes_pls_golite062009
protein binding	1.22353256456298	bayes_pls_golite062009
catalytic activity	0.941400907161877	bayes_pls_golite062009
thiolester hydrolase activity	0.115001587361034	bayes_pls_golite062009
hydrolase activity	0.021392930321391	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: