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View Structure Prediction Details

Protein: chp1
Organism: Schizosaccharomyces pombe
Length: 960 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for chp1.

Description E-value Query
Range
Subject
Range
gi|187028690, gi... - gi|39587799|emb|CAE67817.1| Hypothetical protein CBG13397 [Caenorhabditis briggsae], gi|187028690|em...
gi|157749569 - gi|157749569|ref|XP_001678498.1| Hypothetical protein CBG13397 [Caenorhabditis briggsae AF16]
387.0 [0..49] [590..248]

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Predicted Domain #1
Region A:
Residues: [1-183]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSVKPLPDI DSNEGETDAD VYEVEDILAD RVNKNGINEY YIKWAGYDWY DNTWEPEQNL  60
   61 FGAEKVLKKW KKRKKLIAKG LLEPFDAEDN EAKKMKREKE ILRQQRQKRK SELTQLSQKV 120
  121 KEKFKKMRKK PARRIVTIAN DEEEEDDQTM DEDAFERKSM QGELKERNLT DKTSTLSTSF 180
  181 GET

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.69897
Match: 2b2uA
Description: Tandem chromodomains of human CHD1 complexed with Histone H3 Tail containing trimethyllysine 4 and dimethylarginine 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription repressor activity 4.08500855631983 bayes_pls_golite062009
transcription regulator activity 3.64390820819794 bayes_pls_golite062009
methylated histone residue binding 3.42338304360938 bayes_pls_golite062009
chromatin binding 3.1924157640698 bayes_pls_golite062009
binding 3.06758476214113 bayes_pls_golite062009
nucleic acid binding 2.19167058827256 bayes_pls_golite062009
DNA binding 2.05514577638135 bayes_pls_golite062009
histone binding 2.00388175060339 bayes_pls_golite062009
protein binding 1.61683263008775 bayes_pls_golite062009
general transcriptional repressor activity 0.75184432495983 bayes_pls_golite062009
RNA binding 0.503214578033104 bayes_pls_golite062009
transcription corepressor activity 0.294457188332415 bayes_pls_golite062009
catalytic activity 0.14067200158938 bayes_pls_golite062009
transcription activator activity 0.136090220479238 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [184-434]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPDVNPFYLS EWPTVTDSIL LSKSLSSDAI PLKNGEIKST MLMPSDSDNS VPGIQNSNNL  60
   61 ENTGAFVENA NSPQSNTPLS TFRHSSPLSL SPVITSDNDV ANSLFFSNST PLPSSLKIKK 120
  121 EAPKLETHTI LVSDNSGSLT KQDILSYFAF IKGNIEVFFL KSPKKDKVCN MAYIQFDSIE 180
  181 QAKLAYDKGH PSWHVTLVKG KISTDMEECK VSKSILKTTP SKKANARSVS FTQTTTDTLS 240
  241 ESEKFASNVD L

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [435-586]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DENFDFNVNV TNEDAKQLKK SVIGSSWTTV NNDWNSVSKS DQTFENDGAS KVVPAGNITL  60
   61 NSDNSLHHSI SESEDLSSAS TLSDYFRFVL RVGKSLYYAG ELSFDISKLK AETEHQQLLR 120
  121 SLVSCKQVDV LRFVTSQYLE VFGTCLTKVL SG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.514 0.551 chromosome segregation c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.516 0.130 chromatin silencing at silent mating-type cassette a.1.1 Globin-like
View Download 0.639 0.112 chromatin silencing at silent mating-type cassette a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.467 0.015 chromatin silencing at silent mating-type cassette a.40.1 Calponin-homology domain, CH-domain
View Download 0.503 0.005 chromatin silencing at silent mating-type cassette a.24.10 Histidine-containing phosphotransfer domain, HPT domain

Predicted Domain #4
Region A:
Residues: [587-779]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLCIRSDVDM THFKNILNRG NGAGIVLGSN YTLLLFTEDN NALMNLYDCQ GQSNSPFWMV  60
   61 IFEPLESILV EWSAKNLRPK KPYHKSQSYL SYLLQLGHID LHKIGAFQAT QILIVSKQPS 120
  121 PEAEELEDTF REAAIPTFRG LEIPESLFLS QNVFVFLNVS LEDDFDQLQF LTLAKRKSCK 180
  181 FFLFGLSLPL KSP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [780-960]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDSHVGTDFK KNNEPLDKLT YSQYLRPMFP KGGVVSVTLS ALIKTPRLLE LISPFLEIKK  60
   61 DSWILILPPS IVDMVKSYFV TNNPDKSLLE IQNLLNTLQR YLTNPALKNV TLYQDWDIVI 120
  121 DDSADVSLAS TLQLYQKKNY DKYRRFVLIH ELKNELTPVN GLDIVDYDEF KETFMRAIGL 180
  181 K

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


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