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View Structure Prediction Details

Protein: mcs2
Organism: Schizosaccharomyces pombe
Length: 322 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mcs2.

Description E-value Query
Range
Subject
Range
gi|114599953 - gi|114599953|ref|XP_517728.2| PREDICTED: cyclin B1 [Pan troglodytes]
232.0 [0..12] [294..249]
gi|73949659, gi|... - gi|73988334|ref|XP_851164.1| PREDICTED: similar to G2/mitotic-specific cyclin B1 isoform 1 [Canis fa...
229.0 [0..12] [294..138]
gi|1752809 - gi|1752809|dbj|BAA14010.1| cyclin A [Asterina pectinifera]
229.0 [0..21] [284..175]
gi|60655945 - gi|60655945|gb|AAX32536.1| cyclin B1 [synthetic construct]
228.0 [0..12] [294..146]
CCNB1, CGB1 - chorionic gonadotropin, beta polypeptide 1, cyclin B1
gi|123990181 - gi|123990181|gb|ABM83901.1| cyclin B1 [synthetic construct]
228.0 [0..12] [294..146]
gi|109077471 - gi|109077471|ref|XP_001091170.1| PREDICTED: cyclin B1 isoform 2 [Macaca mulatta]
227.0 [0..12] [294..145]
gi|45725019 - gi|45725019|emb|CAG23923.1| cyclin A protein [Sphaerechinus granularis]
226.0 [0..18] [284..194]

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Predicted Domain #1
Region A:
Residues: [1-322]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSADKFRDST HYRDWIFTEE DLSKTRAKVN EKFTNIVRER MLEELSLQNK EASLEVLPPT  60
   61 LTVEEELELV NYYSFQLNAL SSALSLPTHI RSTAILFFKR FYLINSVMEY SPKIISFTSL 120
  121 FLATKCNDHY ISIEQFCKNM PKTTPEEVLE YEFNVCQSLK WDLYVWLPFR PLQGFLLDCQ 180
  181 TVLPKVAVEK FYECHDLSKK FLIETLHSDI YFLHSPSIIA LGAIYHTNPT ICLQYIEAKK 240
  241 IPELQPLIIS ISANLKATKK FKIEKKKAQD YGRKLYFCMN PLRNKSSALY LKRKAEEEST 300
  301 NNNKWAKKFS TSSNVLDKNP FE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 35.0
Match: 1jkwA
Description: STRUCTURE OF CYCLIN MCS2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 8.12427628405368 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 6.12919068656167 bayes_pls_golite062009
protein kinase regulator activity 2.90083336559452 bayes_pls_golite062009
kinase regulator activity 2.84789294954357 bayes_pls_golite062009
transcription regulator activity 2.795846725429 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.51688704722199 bayes_pls_golite062009
binding 2.4204867358489 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.00665312545368 bayes_pls_golite062009
DNA binding 1.6980508926231 bayes_pls_golite062009
nucleic acid binding 1.63159454080484 bayes_pls_golite062009
protein binding 1.47106731485576 bayes_pls_golite062009
transcription factor activity 1.0145450763465 bayes_pls_golite062009
protein kinase activity 0.957590284872001 bayes_pls_golite062009
kinase activity 0.79567569649664 bayes_pls_golite062009
transcription factor binding 0.749278791251235 bayes_pls_golite062009
enzyme regulator activity 0.729629809946521 bayes_pls_golite062009
protein serine/threonine kinase activity 0.567809158275482 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.561985718866596 bayes_pls_golite062009
kinase binding 0.451409627821468 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.15005807834588 bayes_pls_golite062009
transcription coactivator activity 0.138191616709499 bayes_pls_golite062009
transcription activator activity 0.0696060248241566 bayes_pls_golite062009

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