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View Structure Prediction Details

Protein: ace2
Organism: Schizosaccharomyces pombe
Length: 533 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ace2.

Description E-value Query
Range
Subject
Range
gi|73947291 - gi|73947291|ref|XP_541354.2| PREDICTED: similar to Zinc finger protein 606 (Zinc finger protein 328)...
468.0 [0..3] [531..2344]
gi|109125970 - gi|109125970|ref|XP_001115785.1| PREDICTED: similar to zinc finger protein 665 [Macaca mulatta]
431.0 [0..1] [524..243]
gi|76678552 - gi|76678552|ref|XP_583095.2| PREDICTED: similar to Zinc finger protein 268 (Zinc finger protein HZF3...
425.0 [0..4] [532..649]
ZNF347 - zinc finger protein 347
gi|208968133 - gi|208968133|dbj|BAG73905.1| zinc finger protein 347 [synthetic construct]
412.0 [0..5] [532..270]

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Predicted Domain #1
Region A:
Residues: [1-160]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLSYLSSSS QKSFESFRQE ESPACNHSYQ RDYETFGDSK HTSFSSFAPF ENEVSLNQAV  60
   61 IPSPPSHLQN FQDQFDYSSV LKTPFNPLLE ANSAYFLSNQ ISLPDSHSYA SSFDASLSPP 120
  121 SSPLTCVSQI HTEQNFNNND AFSLTNSQQA FSEIGYDASN 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [161-371]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WIDELDSQQQ VLSFPEFDIP EIKTETCSNK DHLENFDYLS SSIPETSGPA SSVLPSSSQL  60
   61 ESFNEFMFLP SSPPGLDEIN GAPSFEELNF QISQPSPAHP VDLSSPETAP NISPVSPFAQ 120
  121 LVKLEPTSPQ KPSFALDSSF SHLDVCRHTD NQKAFAKLSS PAEYVSEFEK FSSVCDHGLD 180
  181 ISNANINNTL TQQFALSAPY ESCIVTKKPE P

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.39794
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #3
Region A:
Residues: [372-533]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CITVKEEEQL APKIESADLS ITPQVTEHDS KPPVRISYDH RCKTRKQSTR ICRIPPETMA  60
   61 SLYCGPEADG KYVCLYNGCN KRIARKYNVE SHIQTHLSDR PYRCDLCKAG FVRHHDLKRH 120
  121 LRIHENGRPY VCECLKRFNR LDALNRHKQR NICVGGVDRR QH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.69897
Match: 2gliA
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.31369346002275 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
transcription repressor activity 1.64349785387632 bayes_pls_golite062009
chromatin binding 1.53640935908107 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.0497955246512 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009
transcription corepressor activity 0.10558148421807 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle