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View Structure Prediction Details

Protein: Met-PA, FBpp0310182
Organism: Drosophila melanogaster
Length: 716 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Met-PA, FBpp0310182.

Description E-value Query
Range		 Subject
Range
gi|7511950, gi|2... - pir||T09462 juvenile hormone resistance protein - fruit fly (Drosophila melanogaster), gi|2662481|g...
 304.0 [0..1] [716..1]

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Predicted Domain #1
Region A:
Residues: [1-118] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAPETGNTG STGSAGSTGS GSGSGSGSGS SSDPANGREA RNLAEKQRRD KLNASIQELA  60
   61 TMVPHAAESS RRLDKTAVLR FATHGLRLQY VFGKSASRRR KKTGLKGTGM SASPVGDL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.69897
Match: 1am9A
Description: SREBP-1a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
nucleic acid binding 4.75270293029792 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
transcription activator activity 2.5495467409976 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.48787404513864 bayes_pls_golite062009
sequence-specific DNA binding 2.31910036997977 bayes_pls_golite062009
protein binding 1.59929864805879 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 1.46304579811572 bayes_pls_golite062009
transcription repressor activity 0.955588849035129 bayes_pls_golite062009
transcription corepressor activity 0.801830750183111 bayes_pls_golite062009
transcription coactivator activity 0.3513586903977 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [119-244] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNPSLHLTDT LMQLLDCCFL TLTCSGQIVL VSTSVEQLLG HCQSDLYGQN LLQITHPDDQ  60
   61 DLLRQQLIPR DIETLFYQHQ HHQQQGHNPQ QHSTSTSAST SGSDLEEEEM ETEEHRLGRQ 120
  121 QGEADD

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 5.23
Match: 1dp6A
Description: Histidine kinase FixL heme domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.27604928641749 bayes_pls_golite062009
DNA binding 3.83861939247274 bayes_pls_golite062009
nucleic acid binding 3.43738039086015 bayes_pls_golite062009
transcription factor activity 3.18442852449976 bayes_pls_golite062009
binding 3.0194696248926 bayes_pls_golite062009
transcription factor binding 2.22314179303094 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.13819142609078 bayes_pls_golite062009
transcription activator activity 1.8593473738006 bayes_pls_golite062009
protein binding 1.60673447924806 bayes_pls_golite062009
sequence-specific DNA binding 1.54935001412565 bayes_pls_golite062009
transcription cofactor activity 1.06445298547053 bayes_pls_golite062009
transcription coactivator activity 0.934727986222767 bayes_pls_golite062009
protein heterodimerization activity 0.865848090169615 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.614755150740891 bayes_pls_golite062009
histone acetyltransferase binding 0.609670492126344 bayes_pls_golite062009
protein dimerization activity 0.3832620238984 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.119454387636252 bayes_pls_golite062009
transcription repressor activity 0.104316215089923 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [245-607] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEDHPYNRRT PSPRRMAHLA TIDDRLRMDR RCFTVRLARA STRAEATRHY ERVKIDGCFR  60
   61 RSDSSLTGGA AANYPIVSQL IRRSRNNNML AAAAAVAAEA ATVPPQHDAI AQAALHGISG 120
  121 NDIVLVAMAR VLREERPPEE TEGTVGLTIY RQPEPYQLEY HTRHLIDGSI IDCDQRIGLV 180
  181 AGYMKDEVRN LSPFCFMHLD DVRWVIVALR QMYDCNSDYG ESCYRLLSRN GRFIYLHTKG 240
  241 FLEVDRGSNK VHSFLCVNTL LDEEAGRQKV QEMKEKFSTI IKAEMPTQSS SPDLPASQAP 300
  301 QQLERIVLYL IENLQKSVDS AETVGGQGME SLMDDGYSSP ANTLTLEELA PSPTPALALV 360
  361 PPA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.69897
Match: 1wa9A
Description: Crystal Structure of the PAS repeat region of the Drosophila clock protein PERIOD
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [608-716] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSSVKSSISK SVSVVNVTAA RKFQQEHQKQ RERDREQLKE RTNSTQGVIR QLSSCLSEAE  60
   61 TASCILSPAS SLSASEAPDT PDPHSNTSPP PSLHTRPSVL HRTLTSTLR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle