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View Structure Prediction Details

Protein: Rph-PA
Organism: Drosophila melanogaster
Length: 638 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Rph-PA.

Description E-value Query
Range
Subject
Range
gi|73995236 - gi|73995236|ref|XP_853754.1| PREDICTED: similar to rabphilin 3A homolog [Canis familiaris]
402.0 [0..1] [636..1]

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Predicted Domain #1
Region A:
Residues: [1-168]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFQNRNNTA NKFVCPSDRQ LALRAKLKAG WSSSKTSEPL RPEEQEAIIS VIRRNEEIEV  60
   61 AERQRVGRLV ERVEKIKQHA VERGPNCCRL CGDTFGILRP QRILCEDCRQ SVCTKCSVDI 120
  121 NIRYHTSERS REIWLCRICS ETREMWKKSG AWFFKGLPKY DMPRSASA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.522879
Match: 1zbdB
Description: Effector domain of rabphilin-3a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.30634266891018 bayes_pls_golite062009
protein binding 1.32366404206022 bayes_pls_golite062009
phosphoinositide binding 1.14205751938857 bayes_pls_golite062009
phospholipid binding 0.80395524110653 bayes_pls_golite062009
phosphatidylinositol binding 0.41867699028241 bayes_pls_golite062009
transcription regulator activity 0.252619815825555 bayes_pls_golite062009
DNA binding 0.223827909774173 bayes_pls_golite062009
nucleic acid binding 0.107173543930241 bayes_pls_golite062009
transporter activity 0.0727830088566982 bayes_pls_golite062009
histone binding 0.0177836520392798 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [169-337]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPIPNPGPGS MAGDTRAVQS CHATPTRPAR VKKLTIRVND SSSSSSGHSE PEDEVDTGVG  60
   61 IGVGVVGGGM AKGIASTRLQ REDSFRLRAY GSIRSFIDGG ERKLSNSFFF NRQQSQRPSE 120
  121 CPEYDSVSMS KLRRESSFLR RGSVSSSWSI SDSSGSGSNN SGNSQTQSQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [338-638]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YQQHQQQLQQ HCRDPLLGWL EIAISYREAF HSLDCTMVRA RDLPAMDAAG LADPYCKLNI  60
   61 ITPEAHTKYT RWQRTKTVHK TRNPEFNETL QFVGVEPEEL GNSLIYVALF DDDKYGHDFL 120
  121 GAAKVCLSTV HSTSQYRISV PLGVEDQYSN AAEMAQNWPN GKMLLSLCYN TKRRALVVNV 180
  181 KQCINLMAMD NNGSSDPFVK IQLKPDAHKN KKHKTSVKWR TLNPIYNEEF YFEASPHDLN 240
  241 KEMLILTVWD KDLGKSNDFL GSLQLGAQSK GERLQQWLDC IRLPDHFHEK WHCLAPDNPA 300
  301 H

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.0
Match: 1dqvA
Description: Synaptogamin I
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle