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View Structure Prediction Details

Protein: lz-PA
Organism: Drosophila melanogaster
Length: 826 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lz-PA.

Description E-value Query
Range
Subject
Range
gi|4713925 - gi|4713925|gb|AAC47196.2| Lozenge [Drosophila melanogaster]
368.0 [0..1] [826..1]

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Predicted Domain #1
Region A:
Residues: [1-219]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHLHLLAAEK TPPSPSPNPT PTPSASPSGH TGAAGESQLD LASQTESQLQ LGLPLASGYG  60
   61 LGLGLGLGLG LGLGQELVAD HSTTVAPVSV AGPGRLGRSI NGSGGSHHHH HLHHHYSPYH 120
  121 HAHPYHPPHP HAPHHHHHHH PPYPYPPAGP HPPAMVTSSS TSPTGNGWSS STGDFKGITA 180
  181 VATATGGGVG GATQGATAST GATAAEVLAV SSSASVGSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [220-396]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPTGGASNGT AHSGHSGHTG GHSSSTASNN NNNGASNSNS NNNNAVHQDL LWMERLVQKR  60
   61 QQEHPGELVR TSNPYFLCSA LPAHWRSNKT LPMAFKVVAL AEVGDGTYVT IRAGNDENCC 120
  121 AELRNFTTQM KNDVAKFNDL RFVGRSGRGK SFTLTITVAT SPPQVATYAK AIKVTVD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 46.39794
Match: 1e50A
Description: Acute myeloid leukemia 1 protein (AML1), RUNT domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.13591399970354 bayes_pls_golite062009
nucleic acid binding 0.54158309583174 bayes_pls_golite062009
DNA binding 0.53363287856737 bayes_pls_golite062009
transcription regulator activity 0.3602964037518 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [397-524]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GPREPRSKTS PTGGPHYRAL GLGQRPYIDG FPSTKALHEL ESLRRSAKVA AVTTAAAAAA  60
   61 TAASAANAVA AAAAAVAVTP TGGGGGVAAG GVAGGAGAGL VQQLSSNYSS PNSTINSDCQ 120
  121 VYKPNAPH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [525-740]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IQAAEMMGAG EWTNGSSSSA AAYYHSHAHH PHAHHAHAHL QHQMALPPPP PPPAAAPVSV  60
   61 GVGGNGATMG MGMGVGVGMG MNHYGGGYDS ANSLEAGQYA AHLPAVLPEM HGHGFATDPY 120
  121 QTAGYGGGNT GGGSASKSEL DYGGSYNQAW SNGYQNYQYG SCLATAQYGP QAAPPPQPPP 180
  181 PPPVVLCPQL YSTVNQNQIH LHLHSSEKLE QYLGTA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [741-826]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSADHLTIGS LTGSSRSSIE IGQDQYHQQV HHAQQQQQQQ QQQQQVHHPQ QQQVESAGEV  60
   61 GGSGAGGVES AREEDVGDLS QVWRPY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle