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View Structure Prediction Details

Protein: CG1885-PA, FBpp0...
Organism: Drosophila melanogaster
Length: 277 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG1885-PA, FBpp0....

Description E-value Query
Range
Subject
Range
gi|147677308, gi... - gi|98661630|dbj|GAA01338.1| unnamed protein product [Pelotomaculum thermopropionicum SI], gi|1476773...
231.0 [0..2] [263..251]
gi|51245586, gi|... - gi|51245586|ref|YP_065470.1| uroporphyrinogen III synthase/methyltransferase (HemD+CobA) [Desulfotal...
229.0 [0..2] [262..259]
gi|71489436, gi|... - gi|71544542|ref|ZP_00665566.1| Uroporphyrin-III C-methyltransferase, C-terminal [Syntrophobacter fum...
228.0 [0..2] [261..250]
gi|94730811, gi|... - gi|94986562|ref|YP_594495.1| siroheme synthase [Lawsonia intracellularis PHE/MN1-00], gi|94730811|em...
227.0 [0..2] [258..249]
gi|25315418 - pir||AC2237 uroporphyrinogen III methylase [imported] - Nostoc sp. (strain PCC 7120)
gi|17230942, gi|... - gi|17230942|ref|NP_487490.1| uroporphyrinogen III methylase [Nostoc sp. PCC 7120], gi|17132583|dbj|B...
226.0 [0..1] [255..253]
gi|77685636, gi|... - gi|77685636|ref|ZP_00801028.1| Uroporphyrin-III C-methyltransferase, C-terminal [Alkaliphilus metall...
226.0 [0..1] [255..250]
gi|23125855, gi|... - gi|23125855|ref|ZP_00107772.1| COG1587: Uroporphyrinogen-III synthase [Nostoc punctiforme PCC 73102]...
226.0 [0..2] [254..268]
gi|91201153 - gi|91201153|emb|CAJ74212.1| strongly similar to uroporphyrinogen III synthase/methyltransferase [Can...
225.0 [0..2] [262..249]
gi|45510631, gi|... - gi|75909680|ref|YP_323976.1| uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferas...
225.0 [0..1] [255..253]
gi|12655814 - gi|12655814|gb|AAK00606.1|AF221100_3 uroporphyrinogen III synthase/methyltransferase [Selenomonas ru...
225.0 [0..2] [255..256]

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Predicted Domain #1
Region A:
Residues: [1-277]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSRQRTVII FKSESESSDV YAETLEKHDF NPVFVPTLSF GFKNLDELRA KLQNPDKYAG  60
   61 IIFTSPRCVE AVAESLNLGE LPGGWKMLHN YAVGEVTHNL ALSTLDQLFT HGKQTGNARA 120
  121 LGDYIVDTFD GSRALPLLLP CGNLATDTLL SKLAENGFSV DACEVYETRC HPELGANVER 180
  181 ALEIYGESIE FLAFFSPSGV NCAQQYFTSR QLSMDKWKLV AIGPSTRRAL ESLGQKVYCT 240
  241 AERPTVEHLV KVLLNPQDSR ERLLKERERM AAIENNN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.69897
Match: 1jr2A
Description: Uroporphyrinogen III synthase (U3S, HemD)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
uroporphyrinogen-III synthase activity 3.75954315324218 bayes_pls_golite062009
binding 1.39689732651231 bayes_pls_golite062009
catalytic activity 1.13824203225664 bayes_pls_golite062009
hydro-lyase activity 0.290711782955013 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle