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View Structure Prediction Details

Protein: Upf2-PA
Organism: Drosophila melanogaster
Length: 1241 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Upf2-PA.

Description E-value Query
Range
Subject
Range
gi|114629521 - gi|114629521|ref|XP_507656.2| PREDICTED: UPF2 regulator of nonsense transcripts homolog [Pan troglod...
804.0 [0..48] [1240..286]

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Predicted Domain #1
Region A:
Residues: [1-370]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLANDSATTD SEVSTPPSSR KDLADGVAEG DNDNDIDTGD TDANADEDVD AAAAIALEAE  60
   61 EREELQQFIS ELREKIESKR QLRLQNSTIE LPGEEYFAKL DSNLKKNTAF VKKLKLFTAT 120
  121 QLDGLLREIS ALNLSKYISE ICAALVEAKL KMTDVPAVVT LASRLHCTYA DFDVHFLEAW 180
  181 QKALNIKATE KIGNPSKLRV DLRLFAELVS SGVIQMKPGL AQLGVVLVHL IALDKDDHSN 240
  241 FSIILSFCRH CGEEYAGLVP QKMQQLATKY GVEVPKSDFL TADKQLNLRT MLKGYFKALC 300
  301 KHVLAEQAEL MNMTKNIRRT MECKGEISTE KREKCELMQA GFDKLLASAQ SLSELLGEPL 360
  361 PELAKESEGC 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.0
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [371-473]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPGTVIDNML DSASFGVLDP WGDEETRAFY TDLPDLRQFL PNFSAPKVDL ETLEEPSELT  60
   61 EEAIDANLDA EMDLDDPPST TSDTTPENPI EEQPTTPVAA AED

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [474-728]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKPQKMGNAL MELGRQQQQQ SQLNQNPIQI QNQMRQQFDG FLVNLFNCVN KELIDSAAIE  60
   61 FLLNFNTKHQ RKKLTRTIFS VQRTRLDILP YLSRFVAIVH MCNTDVATDL AELLRKEFKW 120
  121 HIHKKNQLNI ETKLKIVRFI GELVKFGLFK KFDALGCLKM LLRDFQHHQI EMACAFVEVT 180
  181 GVYLYNCRDA RLLMNVFLDQ MLRLKTATAM DSRHAAQIES VYYLVKPPES SKREPMVRPA 240
  241 MHEYIRYLIF EELCK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.045757
Match: 1hu3A
Description: Eukaryotic initiation factor eIF4G
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 1.23334705954471 bayes_pls_golite062009
binding 1.13433258588739 bayes_pls_golite062009
protein binding 0.321971103983539 bayes_pls_golite062009
nucleic acid binding 0.222038432626885 bayes_pls_golite062009
catalytic activity 0.0114279309788371 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [729-958]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QNVDRCIKML RRIDWQDPET NCYAIKCLSK AYLLRFQLIR CLADLVSGLS SYQPRAVTIV  60
   61 IDNVFEDIRA GLEIHSPRMA QRRIAMAKYL GEMYNYKLVE STNILNTLYS IISLGVSNDQ 120
  121 NVVSPLDPPD SLFRLKLACM LLDTCAPYFT SQATRKKLDY FLVFFQHYYW FKKSHPVFSK 180
  181 TENTSDLFPI LMDHTYRDCL LNVRPKLKIY KSLEQAKAAI DHLQEKLYPQ 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 96.221849
Match: 1uw4B
Description: The structural basis of the interaction between nonsense mediated decay factors UPF2 and UPF3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 1.23334705954471 bayes_pls_golite062009
binding 1.13433258588739 bayes_pls_golite062009
protein binding 0.321971103983539 bayes_pls_golite062009
nucleic acid binding 0.222038432626885 bayes_pls_golite062009
catalytic activity 0.0114279309788371 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [959-1025]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKTTNNAQDP SLGTISEISE IDEGGTDEDS GSSNDQRERQ VSGQEQDQSN DWTENEAEPP  60
   61 LPPLPPP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1026-1241]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKSKEDLEFE QLYEKMTTDS YQERLKEPIK ATAKDIPVPM MARLQKKSYD QITGAQTIGP  60
   61 GINNMSQISK SVPNQDGTPG SPGADSPDGN GKSGGGVGGS DVGAAGAAGA SGATSVPFVL 120
  121 MVRGHKGGKQ QFKSFVAPSD SHLATNLKRQ EQMIREEKEK VKRLTLNITE RIEEEDYQES 180
  181 LMPPQHRNFT QSYYQKPNKH KFKHQKGAPD ADLIFH

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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Created and Maintained by: Michael Riffle