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View Structure Prediction Details

Protein: C3G-PH
Organism: Drosophila melanogaster
Length: 1571 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for C3G-PH.

Description E-value Query
Range
Subject
Range
gi|25089800 - gi|25089800|sp|O77086|C3G_DROME Guanine nucleotide-releasing factor 2 (CRK SH3-binding GNRP)
880.0 [0..1] [1571..1]

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Predicted Domain #1
Region A:
Residues: [1-171]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPQFDESFLS DCALADRWHF YSYTVKQLPP HPSPKPNRNR NPYPSGASHD DHQHQLHHHH  60
   61 HQQHHHNHHR LWKTQRQSWS PRDTNNNHSL TSNNCNCNSS NTCNSISATG NTLHSIKFHR 120
  121 RRKYKKLARL ALSTPAIPLQ MDVDVDVNVT VDREFDMEMD TPVPLKNAVC H

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.09
Match: 2d2aA
Description: Crystal Structure of Escherichia coli SufA Involved in Biosynthesis of Iron-sulfur Clusters
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [172-353]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSISSPSTPG TCSSGIGVGG GGCSSSSNNS INSGSYSTAC TPPPPTHQHH SQHQQLQGTP  60
   61 GGSSRVGGAG AGGGGGVPPA PPSAGSSGHK NSLKGTKLAR RARSFKDDLI EKISLMRTTN 120
  121 NTLGRSHSPH SPRTKHGTKA PPTTEEVLRS TQTLETHVKD ISNALKHFRD VILKKKLEVL 180
  181 PG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.0
Match: 1x1lA
Description: Interaction of ERA,a GTPase protein, with the 3'minor domain of the 16S rRNA within the THERMUS THERMOPHILUS 30S subunit.
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [354-502]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGTVILETIA SMYSVIQTYT LNENSAIMSS ATLQVYQSLG KLIKLCDEVM LSEDSGECAS  60
   61 LSNENVREVI DLLEDAVRNL VTLAQGKLKE QDQCAFRYSG SGLGGIGAAA EIMGAVTASP 120
  121 GASVPGTGVM RVSAAESAAQ RTSLPDIAL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [503-687]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPKERDILEQ HNVNPMRGSH STESILRDTS PPPKPPLPNR ASNPPPLPPK RRSQPSASAG  60
   61 TVGVGCSSST STSNQASPLP YAQSHNISLN SDLDCSSNIS LLNYGVDRLS VRSRSPDENS 120
  121 QCSFDSALNH SREEEDQQQQ HQHLRSFPKL AAMMDEDMDK MVSYSAAIDD KTQTPLSTGG 180
  181 GIAGV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [688-775]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGGTGGAGEG VAAAASGDGE TNSNRHSNES GFVSMREFRT STQTTDYSVQ SSTKSSSSNS  60
   61 EIAFSISEST AVGSSSEYQQ ISQLVSHS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [776-1000]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QRHISSSSSS CTTTTTSSST TTGYGSSEVE QLQQQQQQQT TTTPADLAPA LPPKSIQRSS  60
   61 LTRHDSPGVG DELDEVQSSS GWASHRSSQS EVAELRQLSP LHHLNHHPHT ASAGQLQQWH 120
  121 SKHHSLIEGP RLQLAGSGSC SAFDQRHLDQ EPPPLPIKKK HILAYMEICS ASTRSIEQHR 180
  181 HTMHACNISR NISHSQTMNI MPMSKELSPE LEMPPALPPK NYKQR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1001-1115]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KATSMVASPT LQPVIVTTPP PSPKPTLGEN GSTGRPDSRM ATVCEELNDA VASEDAMPEP  60
   61 RSPVLDSNEN VSAVDDGQTF YCHSHQLPAA EMEMSEDASS ADNQPITTPQ VLEEQ

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1116-1571]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEPTAESRPL VAVHESVKPA NVDEDEEAER ADMLINMLEE VNITRYLILK KREEDGPEVK  60
   61 GGYIDALIVH ASRVQKVADN AFCEAFITTF RTFIQPIDVI EKLTHRYTYF FCQVQDNKQK 120
  121 AAKETFALLV RVVNDLTSTD LTSQLLSLLV EFVYQLVCSG QLYLAKLLRN KFVEKVTLYK 180
  181 EPKVYGFVGE LGGAGSVGGA GIAGSGGCSG TAGGGNQPSL LDLKSLEIAE QMTLLDAELF 240
  241 TKIEIPEVLL FAKDQCEEKS PNLNKFTEHF NKMSYWARSK ILRLQDAKER EKHVNKFIKI 300
  301 MKHLRKMNNY NSYLALLSAL DSGPIRRLEW QKGITEEVRS FCALIDSSSS FRAYRQALAE 360
  361 TNPPCIPYIG LILQDLTFVH VGNQDYLSKG VINFSKRWQQ YNIIDNMKRF KKCAYPFRRN 420
  421 ERIIRFFDNF KDFMGEEEMW QISEKIKPRG RRPVNY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 125.0
Match: 1xd4A
Description: Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.597587183571285 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.32323692785606 bayes_pls_golite062009
protein binding 0.29116370406325 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle