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View Structure Prediction Details

Protein: Spx-PA
Organism: Drosophila melanogaster
Length: 347 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Spx-PA.

Description E-value Query
Range
Subject
Range
gi|73976801 - gi|73976801|ref|XP_857781.1| PREDICTED: similar to Polyadenylate-binding protein 4 (Poly(A)-binding ...
221.0 [0..7] [346..185]

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Predicted Domain #1
Region A:
Residues: [1-91]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAGPIAERN QDATIYAGGL DDKVSETLLW ELFVQAGPVV NVHMPKDRVT QMHQGYGFVE  60
   61 FLSEEDADYG IKIMNMIKLY GKPIRVNKAS A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.69897
Match: 1x5uA
Description: Solution structure of RRM domain in splicing factor 3B
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 6.73097473547076 bayes_pls_golite062009
6.62953239642182 bayes_pls_golite062009
mRNA binding 5.29759606920196 bayes_pls_golite062009
nucleic acid binding 4.50398990564944 bayes_pls_golite062009
binding 4.16717332578111 bayes_pls_golite062009
snRNA binding 4.06596327298973 bayes_pls_golite062009
poly-pyrimidine tract binding 3.11990160533699 bayes_pls_golite062009
U1 snRNA binding 3.02511982045347 bayes_pls_golite062009
single-stranded RNA binding 2.93798024346416 bayes_pls_golite062009
transcription regulator activity 2.18211199677674 bayes_pls_golite062009
DNA binding 1.73925834998328 bayes_pls_golite062009
structural molecule activity 1.56454315220334 bayes_pls_golite062009
U2 snRNA binding 1.34078165372485 bayes_pls_golite062009
protein binding 1.10597581610211 bayes_pls_golite062009
transcription factor activity 0.873765500321315 bayes_pls_golite062009
mRNA 3'-UTR binding 0.591700155096213 bayes_pls_golite062009
sequence-specific DNA binding 0.294937517750882 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [92-225]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HQKNLDVGAN IFIGNLDVEV DEKLLYDTFS AFGVILQTPK IMRDPETGKS KSFAFINFAS  60
   61 FEASDAAMDA MNGQYLCNRP ISVSYAFKKD HKGERHGSAA ERLLAAQNPS THADRPHQLF 120
  121 ADAPVQTMMP QMPG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 5.0
Match: 1h2tZ
Description: CBP20, 20KDa nuclear cap-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
6.40066880991253 bayes_pls_golite062009
RNA binding 6.32219487559982 bayes_pls_golite062009
mRNA binding 4.87640532914983 bayes_pls_golite062009
nucleic acid binding 4.23531598582972 bayes_pls_golite062009
binding 4.00350364031155 bayes_pls_golite062009
snRNA binding 3.77997752511163 bayes_pls_golite062009
U1 snRNA binding 2.73908382552928 bayes_pls_golite062009
poly-pyrimidine tract binding 2.7133834347239 bayes_pls_golite062009
single-stranded RNA binding 2.55628738360472 bayes_pls_golite062009
transcription regulator activity 2.2045206027152 bayes_pls_golite062009
DNA binding 1.74537942253096 bayes_pls_golite062009
structural molecule activity 1.57342338925793 bayes_pls_golite062009
U2 snRNA binding 1.09350203162237 bayes_pls_golite062009
protein binding 1.04187682253755 bayes_pls_golite062009
transcription factor activity 0.894914712180715 bayes_pls_golite062009
sequence-specific DNA binding 0.238420044364247 bayes_pls_golite062009
mRNA 3'-UTR binding 0.229644510503376 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [226-347]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QIPAQMPGQM MPPPMMAPPP PVVPVSNNNM GMLAPPPPVP QPAPFPATIP PPPLPPMTGG  60
   61 QPPLPPAMGI PPPPRMMQPN AWAPPGMPAP PPRPPPTNWR PPPVPFPPTP YARPYQPDGY 120
  121 QY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.0
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle