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View Structure Prediction Details

Protein: pon-PA
Organism: Drosophila melanogaster
Length: 670 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pon-PA.

Description E-value Query
Range
Subject
Range
gi|3834586 - gi|3834586|gb|AAC71019.1| Partner of Numb [Drosophila melanogaster]
219.0 [0..1] [670..1]

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Predicted Domain #1
Region A:
Residues: [1-189]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLETKSIAAL AFTETPRKRK RETLYKNAAP PPNPQQQPPE KDAQDAAVAS TESCFTNAAF  60
   61 SSTPKKLMVA RRRLAKENSQ PNPFPGLEVK SIADLAQKQQ HQQHHQQQQQ QQQKLPTNPF 120
  121 EVLRQPPKKK KREHACFENP GLNLELPEKQ FNPYEVVRSA TTPAKGFVNP ALNLRGSDAP 180
  181 ASLNPFEIH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [190-350]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPSEASEAAC NPSGVANPAL ADRDSEEQLP TSLKIGLPFT PTLGCRIDFH GMSLTQLTPS  60
   61 KLLAEKLVFS PVPAPKRSLG AISEESSMDI GKELDRYQLE LENSINEAKL RKNGVLVDRE 120
  121 LPRNSLEVEL PKNTKVSLVM ETNTQELMMQ EVVTVDTQVE R

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.09691
Match: 2h94A
Description: No description for 2h94A was found.

Predicted functions:

Term Confidence Notes
binding 1.95113868888523 bayes_pls_golite062009
transcription regulator activity 1.67817541368103 bayes_pls_golite062009
DNA binding 1.65628621585174 bayes_pls_golite062009
transcription factor activity 1.2199858816759 bayes_pls_golite062009
nucleic acid binding 1.06610635349341 bayes_pls_golite062009
protein binding 0.853351196918381 bayes_pls_golite062009
sequence-specific DNA binding 0.79002371725751 bayes_pls_golite062009
cytoskeletal protein binding 0.492703104512863 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.42857545583097 bayes_pls_golite062009
transcription activator activity 0.0621386040786331 bayes_pls_golite062009
actin binding 0.0317334287062701 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [351-670]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLVCTRRRTL TEISEASEVE EDTEKLLEQD REAEVILEQE KILEQEMVSE RERHLTREKQ  60
   61 LKQEKLLERE KHLEREKLQE KLHEQLREKL QERAKHLEKE KLEEEELLER QLEEEREKEP 120
  121 TDGDVAYASE SESDDEPDDL DFKAPARFVR AYRPAALPSK AASKESLQSI GSSKSAKSAE 180
  181 VKPSIGMKGM IRKSIRRLMH PTSHTTPSEV KSEDKDEHGH GQGHGQHNIL NSIRHSLRRR 240
  241 PQKAAELEEQ MEPVLADVSI IDTSERTMKL RSSVAQTEYM TIEQLTNEKK HSLRNSIRRS 300
  301 TRDVLRHVFH KSHDAYATAK 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.30103
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle