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View Structure Prediction Details

Protein: FBpp0310168, rb-...
Organism: Drosophila melanogaster
Length: 1160 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0310168, rb-....

Description E-value Query
Range
Subject
Range
gi|7511814, gi|3... - gi|8071835|gb|AAF71924.1|AF247194_1 ruby [Drosophila melanogaster], pir||T13713 beta3 protein - frui...
868.0 [0..1] [1160..1]

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Predicted Domain #1
Region A:
Residues: [1-692]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQNSASNPF AMSTYVERPQ MGLDVEFGAD PASGAAFFQS DGRKHDDLKQ MLDSNKDGLK  60
   61 LEAMKRIIGM IARGRDASDL FPAVVKNVVS KNIEVKKLVY VYLVRYAEEQ QDLALLSIST 120
  121 FQRALKDPNQ LIRASALRVL SSIRVSMIVP IVMLAIRDSA ADLSPYVRKT AAHAIPKLYS 180
  181 LDADQKDELV MVIEKLLSDR TTLVVGSAVM AFDEVCPERV DLIHKNYRKL CNFLLDVDEW 240
  241 GQVIIINMLT RYARTQFVDP NADDEDLVND GLGETPVSER FYDESSHSSS HSDDGSSDDE 300
  301 KNKSSTNNKN NGGGNGSRTP SSPSNSYHID VDHRLLLRQT KPLLQSRNAS VVMAVAQLYH 360
  361 HVAPKNEVQL IAKALIRLLR SHKEVQSVVL NCIASMSTKR KAIFEPHLKS FFVRTSDPTH 420
  421 IKLLKLDILT NLASAGSISL ILREFQTYIS SSDRSFVAAT IQAIGRCASS IKEVTETCLS 480
  481 GLVHLLSNHD EHVVAESVVV IKRLLQTKAA EHFEIITQMA KLIDYINVPA ARAAIIWLIG 540
  541 EYNEKVPLIA PDVLRKMAKS FVDEQDVVKL QVLNLGVKLY LTNPEQTSLL CQYVFTLARY 600
  601 DPNYDVRDRA RFLRQIIFPA SGTSSVLSQH ARQVFLASKP APVPESKYRD GNNFQLGSLS 660
  661 HYLNMPAAGY KELPAFPVIP PDSSVRNIAG FM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 124.0
Match: 1gw5B
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
clathrin binding 3.59686293424084 bayes_pls_golite062009
binding 2.6374633159018 bayes_pls_golite062009
protein transporter activity 1.89064797870418 bayes_pls_golite062009
protein binding 1.73688475473996 bayes_pls_golite062009
nucleic acid binding 1.49303189891558 bayes_pls_golite062009
transporter activity 1.23282648733451 bayes_pls_golite062009
substrate-specific transporter activity 0.820796192007653 bayes_pls_golite062009
transcription regulator activity 0.776371008347153 bayes_pls_golite062009
DNA binding 0.722443852840929 bayes_pls_golite062009
transcription factor activity 0.118119079678823 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.065389787765811 bayes_pls_golite062009
kinase activity 0.022490934605857 bayes_pls_golite062009
protein kinase activity 0.017827998785715 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [693-750]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDKLPGEDSP SGHSKDKSGR EGGKEKGAGG EKGFLSESDD KSSAYSESGS SSGSGTSD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [751-921]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SESDSDGSGS SDEEEEEVQK QQPTKVSSVK ERLIDAGSNE LAATSSPVKA TINNNNNARG  60
   61 SSGTSDSEDS SAYSGSSSDD SASGSDNEVK KNETKTDTGT KPEKLKEKHE KQPEQTAVKS 120
  121 NLDLLLDLDD IPPIGPVMTP SLGGFLTPGT PMMAGQAAPL QPQHARNRVE L

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [922-1014]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGPSHIEFKH KELLNKVSGH GLHLAYRFTR SPHLYSSSMC SIELQFQNRG EKEITAIRLG  60
   61 QTTLPAGMQL NEFAPITVLQ PQQTASGVLG VDF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.69897
Match: 1iu1A
Description: Gamma1-adaptin domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.93554535044651 bayes_pls_golite062009
protein binding 1.17960228368657 bayes_pls_golite062009
transporter activity 0.169557557237959 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [1015-1160]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDSTHAVDLE LLSSAGSSRL QLKPPVGELV RSVQIGESCH REERAKLRGM NEHQCELRGL  60
   61 RQDLIDVVAL RQKVFESINV AHTHSSSSGQ LHCFAGQTLS SKSLVLLTLD WKTEDALTLL 120
  121 VNCEKMVIGS MVLNELRNAL QLSFAM

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.6
Match: 1w80A
Description: Crystal structure of the alpha-adaptin appendage domain, from the AP2 adaptor complex, bound to 2 peptides from Synaptojanin170
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle