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View Structure Prediction Details

Protein: Xpac-PA
Organism: Drosophila melanogaster
Length: 296 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Xpac-PA.

Description E-value Query
Range
Subject
Range
gi|1255595 - gi|1255595|dbj|BAA06690.1| Dxpa protein [Drosophila melanogaster]
358.0 [0..1] [296..1]
gi|60654147 - gi|60654147|gb|AAX29766.1| xeroderma pigmentosum complementation group A [synthetic construct]
309.0 [0..1] [296..1]
gi|61357324, gi|... - gi|61357324|gb|AAX41371.1| xeroderma pigmentosum complementation group A [synthetic construct], gi|1...
XPA - xeroderma pigmentosum, complementation group A
309.0 [0..1] [296..1]
gi|84579859, gi|... - gi|84579859|ref|NP_001033770.1| xeroderma pigmentosum, complementation group A [Bos taurus], gi|8375...
308.0 [0..1] [296..1]

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Predicted Domain #1
Region A:
Residues: [1-71]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAEVSTNES APPAEKKSKL TNAQKARIER NQAKAQKLRE AKLVSHPFKE LASNKEGGTH  60
   61 PEAALSQGSS V

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.449 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.378 N/A N/A a.179.1 Replisome organizer (g39p helicase loader/inhibitor protein)
View Download 0.363 N/A N/A a.179.1 Replisome organizer (g39p helicase loader/inhibitor protein)
View Download 0.342 N/A N/A a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.335 N/A N/A a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1

Predicted Domain #2
Region A:
Residues: [72-296]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKVQGTKYID SGGGFLLEQP VMPTGVGPAG LNKSGEEAPP ILDDAIAIPV QYEECLECGD  60
   61 MFADSYLFNN FGHSVCDKCR DKDERYALIT RTEAKAEYLL KDCDFDKREP KLRYISRKNP 120
  121 HNVRWGEMKL YLHLQIHQRA LEVWGSEEEL VRQHEAREDK REEGKARKYN KKMKQLRMEV 180
  181 RSSIYTKKTH EVHEHEFGPD TYDEEEDTYT HTCITCPYSE TYEKM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.69897
Match: 1xpaA
Description: SOLUTION STRUCTURE OF THE DNA-AND RPA-BINDING DOMAIN OF THE HUMAN REPAIR FACTOR XPA, NMR, 1 STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.96409924710655 bayes_pls_golite062009
protein binding 2.44501340584871 bayes_pls_golite062009
transcription regulator activity 2.22839475692516 bayes_pls_golite062009
DNA binding 2.18702281581791 bayes_pls_golite062009
nucleic acid binding 2.04270847321412 bayes_pls_golite062009
transcription activator activity 1.60639114794515 bayes_pls_golite062009
sequence-specific DNA binding 1.59705128803795 bayes_pls_golite062009
transcription factor activity 1.44182975349714 bayes_pls_golite062009
structure-specific DNA binding 0.610805977602876 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 0.55799224325565 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.51536225088963 bayes_pls_golite062009
transcription factor binding 0.43597775400036 bayes_pls_golite062009
transcription coactivator activity 0.42962641193703 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.37925266318051 bayes_pls_golite062009
double-stranded DNA binding 0.280685154942276 bayes_pls_golite062009
receptor activity 0.230063209127305 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.10722537662857 bayes_pls_golite062009
catalytic activity 0.101795606736461 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle