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View Structure Prediction Details

Protein: pn-PA
Organism: Drosophila melanogaster
Length: 405 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pn-PA.

Description E-value Query
Range
Subject
Range
gi|103418, gi|23... - gi|235961|gb|AAA04887.1| prune [Drosophila melanogaster], gi|228160|prf||1717395A prune gene, pir||S...
276.0 [0..41] [405..1]

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Predicted Domain #1
Region A:
Residues: [1-405]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCFLRFLAQA RGTLGRHLAE ASPVAWAAAP DVSGRKLHLV MGNESCDLDS AVSAVTLAFV  60
   61 YAQRHREHDY VPILNIPRRD YPLKTEVGHL FVKCGIAEPV LLFRDDIPRE VVQDVNVILV 120
  121 DHHVSPLAPN VTEILDHRPL EDSSPSFKQL PTLCQLDIDA SVGSCATLVA QRYLAEDQPR 180
  181 STSVAQLLHA TIVLDTINFA PAAKRYGPKD EAMVQKLESE LNRKDAQRSS LFDELVAARA 240
  241 DISKLTLTEV LRKDMKVLQT DRQVVPLAGM PILVRDFVEK SGAEKAVREF GVESNLLVIL 300
  301 GMYVSPADGQ VQRDLALISL SGQGQFVQRV QQALMESNDP KLELRPHEVD TRFMGGCFLR 360
  361 QHNVQATRKH ILPIVKRALL EWEADHACDC DEVYFFKEKP QLGLS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 55.0
Match: 1k23A
Description: Manganese-dependent inorganic pyrophosphatase (family II)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nuclease activity 2.22762374984422 bayes_pls_golite062009
hydrolase activity 2.11996205929773 bayes_pls_golite062009
catalytic activity 1.78154379547895 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.7679956422453 bayes_pls_golite062009
deoxyribonuclease activity 1.7238398802096 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1.48438369225803 bayes_pls_golite062009
exonuclease activity 1.4791620684568 bayes_pls_golite062009
binding 1.44809983424821 bayes_pls_golite062009
single-stranded DNA specific exodeoxyribonuclease activity 1.10404503151762 bayes_pls_golite062009
exodeoxyribonuclease activity 0.808006273031307 bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters 0.792120683260194 bayes_pls_golite062009
protein binding 0.409982335293186 bayes_pls_golite062009
inorganic diphosphatase activity 0.158887418739632 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle