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View Structure Prediction Details

Protein: eIF4E-7-PA
Organism: Drosophila melanogaster
Length: 429 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for eIF4E-7-PA.

Description E-value Query
Range
Subject
Range
gi|125978066|ref... - GA17897-PA [Drosophila pseudoobscura], GA28658 [Drosophila pseudoobscura pseudoobscura]
gi|54641817, gi|... - gi|54641817|gb|EAL30567.1| GA28658 [Drosophila pseudoobscura pseudoobscura], gi|125978066|ref|XP_001...
290.0 [0..167] [429..1]

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Predicted Domain #1
Region A:
Residues: [1-207]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPNSFYRMR DFANPRTMFK SCANNNEYPT QGPQKVESPT DVTQPAAAPQ STEDTQPEKT  60
   61 QEPMNDPNKT SPSEPQKRGK GNRKGKKNQK NAPRTPSQTS KSSRSNNPGK DGKSTGNDDN 120
  121 EKGKGQGKQM VQQKENSPEQ EQSTSAQYRK NVLDKDLQDK KLIEKNMQGK IITQENLLGQ 180
  181 KVLMRLSEQK LLSLRLEPRI KQNTCPP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.154902
Match: 1y0fB
Description: No description for 1y0fB was found.

Predicted Domain #2
Region A:
Residues: [208-429]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKKEDAVVAF DNSLEFLSLN NKCDDDLTIA AENAELLEVE DPQHPLNNCW TLWYLENDRN  60
   61 KSWEEMLHKV TSFDTVEKFW SLITHIKPPS ELMLGSDYSL FKKGIRPMWE DEANVNGGRW 120
  121 VINLTKSAKM ALDSFWMDAM LCLIGEACKH SDDLCGVVVN IRGKSNKISI WNADGGNQTT 180
  181 VLEIGRILRK VLRMDNIYVL EYQLHKDSKD KLGSTVKRIY TV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 77.69897
Match: 1ipbA
Description: Translation initiation factor eIF4e
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
translation initiation factor activity 12.6022960879923 bayes_pls_golite062009
RNA cap binding 9.58762092856452 bayes_pls_golite062009
translation factor activity, nucleic acid binding 7.91586572659635 bayes_pls_golite062009
translation regulator activity 7.87578736455963 bayes_pls_golite062009
nucleic acid binding 3.46353214508261 bayes_pls_golite062009
binding 2.88787215275737 bayes_pls_golite062009
RNA binding 2.50528352006389 bayes_pls_golite062009
protein binding 0.873044754151905 bayes_pls_golite062009
RNA 7-methylguanosine cap binding 0.544036568660606 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle