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View Structure Prediction Details

Protein: vnd-PA
Organism: Drosophila melanogaster
Length: 723 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for vnd-PA.

Description E-value Query
Range
Subject
Range
gi|3929674 - gi|3929674|emb|CAA21410.1| EG:118B3.1 [Drosophila melanogaster]
221.0 [0..1] [723..1]

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Predicted Domain #1
Region A:
Residues: [1-99]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTSASLERT PSKRDRDRER DNSSGLGSAG SLPASPQSAI TVSPSSPATP KRPLRTSTPS  60
   61 LERKREREDR EDREDRKERQ ERHERDRDHE RFAAVFSTA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [100-244]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STTVPTNTSS SSGLAPEQLR IPTGAAAFSG FPGLHSMSSL MLPSSAAVAA AAAAPFLPWS  60
   61 PILLPPWNHA LLPAAFYPAA LRNALPGLFD AKVPSSQRSG FHISDILNLE GSELKNAAAA 120
  121 AAAAAHHGSD LSHHSASEST SGHRG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [245-410]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QGSHTSPSAL SPTPAGVSAD EHHNGSGTGG GAGEADHHST TEHHAPPSHP QQQHPHHQQH  60
   61 HHPHLLLPQQ HHQQAVAPLP LAHHQSGEAQ SHAHANAAAA HLLASHNAAA AAAVAAGQYL 120
  121 PNLPKNFPGS FGDEMSSYHH MAQTMLQHSG RSAWIKENEL YGTQQP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.0
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.33505905753956 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [411-543]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASPDSTSPVT SEVSYTYIGS NCQTSPALSG DYKSYSRSAD SDALSVGDAL HTLHGSSGNG  60
   61 SAGGAPTAHA LHNNNNNTTN NNNHSLKAEG INGAGSGHDD SLNEDGIEED IDDVDDADGS 120
  121 GGGDANGSDG LPN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [544-619]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKRKRRVLFT KAQTYELERR FRQQRYLSAP EREHLASLIR LTPTQVKIWF QNHRYKTKRA  60
   61 QNEKGYEGHP GLLHGH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.221849
Match: 1nk2P
Description: VND/NK-2 protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.33505905753956 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [620-723]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ATHPHHPSAL PSPRRVAVPV LVRNGKPCLG DSSKLGADCV SVSSATATAM QNAAAHHLVA  60
   61 LNGAAAYQHA AAAAAGLHAH AHAHAHAHGH GHPHAHAQRA AWWP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle