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View Structure Prediction Details

Protein: pho-PB, pho-PA
Organism: Drosophila melanogaster
Length: 520 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pho-PB, pho-PA.

Description E-value Query
Range
Subject
Range
gi|76651068 - gi|76651068|ref|XP_887912.1| PREDICTED: similar to zinc finger protein 192 isoform 5 [Bos taurus]
654.0 [0..2] [519..333]

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Predicted Domain #1
Region A:
Residues: [1-235]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAYERFGIIL QSEQYDEDIG NTKVNQKMNE GNHYDLHRKN AFDRIIHSES KKGDNVINYN  60
   61 IHENDKIKAA DNIFSSKLKM NPNMSYEMNI NCFKNIGYGE NQETSKVLTN SLSNNDINTE 120
  121 ESGVVDKNSP FLTLGTTILN SNGKSRRWEQ KLVHIKTMEG EFSVTMWASG ISDDEYSGSD 180
  181 QIVGASDLLK GKEEFGIDGF TSQQNKEYQK MESKFTNAQT LEMPHPISSV QIMDH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 53.30103
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #2
Region A:
Residues: [236-329]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LIKERGNLSQ ENNISERILS KTTLSFEEPI LLPDSSSIEL VNETAAMTIN NHRTLSNHTG  60
   61 NTGDLHALPS SVPFRIGLHE GQVNDCLSTI SQST

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.30103
Match: 1x6hA
Description: Solution structures of the C2H2 type zinc finger domain of human Transcriptional repressor CTCF
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
transcription repressor activity 3.27542149084008 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.31369346002275 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
chromatin binding 1.53640935908107 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
transcription corepressor activity 1.34049786451995 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.0497955246512 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription coactivator activity 0.912796194488319 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009
structure-specific DNA binding 0.240825841910931 bayes_pls_golite062009
histone binding 0.0619529561600476 bayes_pls_golite062009
double-stranded DNA binding 0.0129353639725593 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [330-520]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HQDNTDSTGC GEMNLSEVTV SYTNDKKIAC PHKGCNKHFR DSSAMRKHLH THGPRVHVCA  60
   61 ECGKAFVESS KLKRHQLVHT GEKPFQCTFE GCGKRFSLDF NLRTHVRIHT GDRPFVCPFD 120
  121 ACNKKFAQST NLKSHILTHA KAKRNTSISG KSGCSNAESN SQSEDTSANY VKVELQDSVT 180
  181 ENHVPFVVYA D

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.522879
Match: 1ubdC
Description: Ying-yang 1 (yy1, zinc finger domain)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle