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View Structure Prediction Details

Protein: FBpp0311451, Hcf...
Organism: Drosophila melanogaster
Length: 1500 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0311451, Hcf....

Description E-value Query
Range
Subject
Range
gi|13507075 - gi|13507075|gb|AAK28427.1|AF251006_1 host cell factor HCF [Drosophila melanogaster]
538.0 [0..1] [1500..1]

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Predicted Domain #1
Region A:
Residues: [1-390]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEGSDFVDPA FSSGERISAS DLNSEHIIQA ENHSFANRIS MDMDVPDGHQ LDSNLTGFRW  60
   61 KRVLNPTGPQ PRPRHGHRAI NIKELMVVFG GGNEGIVDEL HVYNTVTNQW YVPVLKGDVP 120
  121 NGCAAYGFVV EGTRMFVFGG MIEYGKYSNE LYELQATKWE WRKMYPESPD SGLSPCPRLG 180
  181 HSFTMVGEKI FLFGGLANES DDPKNNIPKY LNDLYILDTR GVHSHNGKWI VPKTYGDSPP 240
  241 PRESHTGISF ATKSNGNLNL LIYGGMSGCR LGDLWLLETD SMTWSKPKTS GEAPLPRSLH 300
  301 SSTMIGNKMY VFGGWVPLVI NDSKSTTERE WKCTNTLAVL DLETMTWENV TLDTVEENVP 360
  361 RARAGHCAVG IQSRLYVWSG RDGYRKAWNN 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.0
Match: 1u6dX
Description: Crystal structure of the Kelch domain of human Keap1
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [391-452]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QVCCKDLWYL EVSKPLYAVK VALVRASTHA LELSWTATTF AAAYVLQIQK IEQPLNTSSK  60
   61 LL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [453-531]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNNIVQQGTP TSAETSGINI SANRSGSALG LGVEATSTVL KLEKESLQLS GCQPETNVQP  60
   61 SVNDLLQSMS QPSSPASRA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [532-590]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKDPLSSGGG TTFNLSTSVA SVHPQISVIS STAAVTGNDT ASPSGAINSI LQKFRPVVT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [591-733]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AVRTSTTTAV SIATSTSDPL SVRVPSTMSA NVVLSSSSST LRIVPSVTAS HSLRIASSQA  60
   61 SGNNCRSSSA INILKTALPN VAVQSQPTSS TTTSIGGKQY FIQKPLTLAP NVQLQFVKTS 120
  121 GGMTVQTLPK VNFTASKGTP PHG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [734-814]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISIANPHLAS GITQIQGSTV PGSQIQKPIV SGNVLKLVSP HTMAGGKLIM KNSNILQMGK  60
   61 VTPNVMGGKP AFVITNKQGT P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [815-940]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGNQQIIIVT TGGNVRSVPT STVMTSAGGS ASGTNIVSIV NSTSTTPSPL QALSGQKTLI  60
   61 SNQSGVKMLR NISSVQASSS MAFGQKQSGT PIHQKTALYI GGKAVTVMST NTSMAASGNK 120
  121 VMVLPG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [941-1180]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSSNNSPATT TALSARKSFV FNAGGSPRTV TLATKSINAK SIPQSQPVTE TNNHSVATIK  60
   61 DTDPMDDIIE QLDGAGDLLK LSESEGQHGS EENENNGENA TSSSASALFT GGDTAGPSRA 120
  121 QNPIVMEHPV DIIEDVSGVS STTDVNETAI VSGDTIESLK MSEKENDDVK SMGEKSILSD 180
  181 DCHQPTTSET EAATILTTIK SAEALVLETA EIRKDHTGCT IGSLKENQDE NKKFKQRQES 240
  241 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1181-1354]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SPSQNIHQFQ NVDGSQLEAL ASAALLQAAT SDTTALALKE LIERPESETN TRSSNIAEIQ  60
   61 QNNVQSTLAV VVPNTSQNEN QKWHTVGVFK DLSHTVTSYI DSNCISDSFF DGIDVDNLPD 120
  121 FSKFPRTNLE PGTAYRFRLS AINSCGRGEW GEISSFKTCL PGFPGAPSAI KISK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.03
Match: 1zlgA
Description: No description for 1zlgA was found.

Predicted Domain #10
Region A:
Residues: [1355-1500]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVKEGAHLTW EPPPAQKTKE IIEYSVYLAV KPTAKDKALS TPQLAFVRVY VGAANQCTVP  60
   61 NASLSNAHVD CSNKPAIIFR IAARNQKGYG PATQVRWLQD PAAAKQHTPT VTPNLKRGPE 120
  121 KSTIGSSNIA NTFCSPHKRG RNGLHD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.045757
Match: 1wftA
Description: Solution structure of C-terminal fibronectin type III domain of mouse 1700129L13Rik protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.12471204223368 bayes_pls_golite062009
protein binding 2.19476891312192 bayes_pls_golite062009
nucleic acid binding 1.46679592932696 bayes_pls_golite062009
transcription regulator activity 1.46015530818566 bayes_pls_golite062009
DNA binding 1.31479811147611 bayes_pls_golite062009
receptor activity 1.09869678752178 bayes_pls_golite062009
transmembrane receptor activity 0.973029129105242 bayes_pls_golite062009
transcription coactivator activity 0.75571850752672 bayes_pls_golite062009
interleukin-6 receptor activity 0.718898152168871 bayes_pls_golite062009
interleukin-6 binding 0.718898152168871 bayes_pls_golite062009
ciliary neurotrophic factor receptor activity 0.69178447295342 bayes_pls_golite062009
transcription factor activity 0.663380108686544 bayes_pls_golite062009
cytokine binding 0.615170922526876 bayes_pls_golite062009
protein kinase activity 0.336349457621575 bayes_pls_golite062009
cytokine receptor activity 0.320890688774472 bayes_pls_golite062009
molecular transducer activity 0.256712571555851 bayes_pls_golite062009
signal transducer activity 0.256712571555851 bayes_pls_golite062009
transcription activator activity 0.221147458438061 bayes_pls_golite062009
structural molecule activity 0.18965275490219 bayes_pls_golite062009
transcription factor binding 0.183613617278749 bayes_pls_golite062009
cytoskeletal protein binding 0.116377273702831 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.0173897395472495 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle