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View Structure Prediction Details

Protein: Dr-PA
Organism: Drosophila melanogaster
Length: 515 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dr-PA.

Description E-value Query
Range
Subject
Range
gi|1098680, gi|2... - gi|2253498|gb|AAB62975.1| muscle segment homeobox [Drosophila melanogaster], sp|Q03372|HMSH_DROME Mu...
121.0 [0..1] [515..1]

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Predicted Domain #1
Region A:
Residues: [1-180]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKLSPASMT VTGLRQTMTS PTVPPSSNTP AGNLIITSSS SNSGSNSGSN MSSGNMTSSN  60
   61 LTNLSPSHPA GLNALASPTS PSALLLAHQQ HLLQQHQQHQ QQQQQQQQAA ALQLAAVHPP 120
  121 AHHLHKTTSR LSNFSVASLL ADTRPRTPPN QAADGPQNLT SSAATSPISQ ASSTPPPPPA 180
  181 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.154902
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [181-414]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SAAAQVPANT FHPAAVAHHA HLLQAAHAAA AAHAQHQAMA AQLRQQQQQA DARANSPPAS  60
   61 TSSTPSSTPL GSALGSQGNV ASTPAKNERH SPLGSHTDSE LEYDEEMLQD HEADHDEEED 120
  121 SIVDIEDMNA DDSPRSTPDG LDGSGKSLES PHGPPPGSHM QSTILSPAAL ASGHVPIRPT 180
  181 PFSALAAAAV AWTGMGGGVP WPGTRQMPPF GPPGMFPGAG FGGDANEPPR IKCN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [415-515]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LRKHKPNRKP RTPFTTQQLL SLEKKFREKQ YLSIAERAEF SSSLRLTETQ VKIWFQNRRA  60
   61 KAKRLQEAEI EKIKMAALGR GAPGAQWAMA GYFHPSLMHL G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.0
Match: 1ig7A
Description: Msx-1 homeodomain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.20953772435302 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 0.876241359231159 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle