YRC Public Data Repository - Protein Structure Prediction

Protein:	eIF4E-6-PC, eIF4...
Organism:	Drosophila melanogaster
Length:	173 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for eIF4E-6-PC, eIF4....

Description	E-value	Query Range	Subject Range
gi\|125978064, gi... - gi\|54641816\|gb\|EAL30566.1\| GA19843-PA [Drosophila pseudoobscura], gi\|125978064\|ref\|XP_001353065.1\| G...	238.0	[0..14]	[169..55]
gi\|50746789 - gi\|50746789\|ref\|XP_420655.1\| PREDICTED: similar to eIF-4E [Gallus gallus]	231.0	[0..2]	[170..55]
gi\|5059071 - gi\|5059071\|gb\|AAD38903.1\|AF128806_1 cap binding protein eIF-4E [Oryzias latipes]	223.0	[0..14]	[172..14]
eIF-4E-PE, eIF-4... - The gene Eukaryotic initiation factor 4E is referred to in FlyBase by the symbol Dmel\eIF-4E (CG4035...	220.0	[0..20]	[169..68]
gi\|39592694, gi\|... - gi\|39592694\|emb\|CAE62308.1\| Hypothetical protein CBG06370 [Caenorhabditis briggsae], gi\|187033964\|em...	220.0	[0..4]	[172..3]
ife-3 - translation initiation factor status:Confirmed UniProt:O61955 protein_id:AAC17807.1	219.0	[0..4]	[172..3]
gi\|94370433 - gi\|94370433\|ref\|XP_930840.2\| PREDICTED: similar to eIF-4E [Mus musculus]	218.0	[0..14]	[170..18]

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Predicted Domain #1

Region A:
Residues: [1-173]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENLRQTKES SEFKMGTSLD NNKLASLGAT NKHRLQNTWT LWGVKYDPEI SWEDMLKEID  60
   61 SFNTVEDFWN LYFRIDTPSK LNRGCDYMLF KKGIRPMWED PPNKGGGRWT YKVDKRSTAE 120
  121 LDKTWLDVLL CMIGEACDHC DQICGAFVRI RKNINKISVW TKADAGDECN EQC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	56.69897
Match:	1ipbA
Description:	Translation initiation factor eIF4e
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
translation initiation factor activity	5.77463400860205	bayes_pls_golite062009
RNA cap binding	5.36300847021001	bayes_pls_golite062009
translation factor activity, nucleic acid binding	4.77719689034956	bayes_pls_golite062009
translation regulator activity	4.73214731999202	bayes_pls_golite062009
binding	1.48722651678341	bayes_pls_golite062009
RNA binding	0.95346802328085	bayes_pls_golite062009
nucleic acid binding	0.60395382190349	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: