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View Structure Prediction Details

Protein: ro-PB, ro-PA
Organism: Drosophila melanogaster
Length: 350 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ro-PB, ro-PA.

Description E-value Query
Range
Subject
Range
gi|85131 - gi|85131|pir||A30046 homeotic protein rough - fruit fly (Drosophila melanogaster)
140.0 [0..1] [350..1]

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Predicted Domain #1
Region A:
Residues: [1-145]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQRHKVEIGS PDGSPGIKRS DSLDPIANTT ILSVPQRPSS PRQFFERLYG HLETRSSENG  60
   61 EIDVGTHAHK PPPCDTPYHS DGGSVSSPDI SISDERTSLA AYPAYDFYGH AKDYPQHPSQ 120
  121 QHQQHHHHHH HPPQLVHQKL SYVSP

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.05
Match: 2awzA
Description: Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5h)
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [146-253]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPAIAAGGAA NPVLPHAFPA GFPSDPHFSA GFSAFLARRR RKEGRQRRQR TTFSTEQTLR  60
   61 LEVEFHRNEY ISRSRRFELA ETLRLTETQI KIWFQNRRAK DKRIEKAQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.0
Match: 1b72A
Description: Homeobox protein hox-b1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 1.04132983826241 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [254-350]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDQHYRNFVV ANGFMSSIMG QAATTMPPGG VTGGVAVGVG LNYYAAAATP AALPKDNTQD  60
   61 ANFIDIDDQF QRQQQQKQQQ QQQQQRRRET TTPINIC

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle