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View Structure Prediction Details

Protein: HLHmgamma-PA
Organism: Drosophila melanogaster
Length: 205 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HLHmgamma-PA.

Description E-value Query
Range
Subject
Range
gi|195349603, gi... - gi|195349603|ref|XP_002041332.1| GM10294 [Drosophila sechellia], gi|194123027|gb|EDW45070.1| GM10294...
gi|55715447, gi|... - gi|55715447|gb|AAV59238.1| enhancer of split complex mgamma protein [Drosophila simulans], gi|195574...
147.0 [0..1] [205..1]
gi|8080 - gi|8080|emb|CAA47434.1| helix-loop-helix protein [Drosophila melanogaster]
147.0 [0..1] [205..1]
gi|195504154, gi... - gi|55714899|gb|AAV59023.1| enhancer of split mgamma protein [Drosophila yakuba], gi|195504154|ref|XP...
146.0 [0..1] [205..1]
gi|54638914, gi|... - gi|54638914|gb|EAL28316.1| GA20996 [Drosophila pseudoobscura pseudoobscura], gi|125776118|ref|XP_001...
gi|54638914|gb|E... - GA20996-PA [Drosophila pseudoobscura], GA20996 [Drosophila pseudoobscura pseudoobscura]
136.0 [0..1] [205..1]
gi|1279398, gi|1... - gi|18858799|ref|NP_571154.1| hairy-related 6 [Danio rerio], gi|1279398|emb|CAA65998.1| HER-6 protein...
133.0 [0..4] [205..87]
gi|4587146 - gi|4587146|dbj|BAA76633.1| newt HES1 [Cynops pyrrhogaster]
131.0 [0..6] [205..26]
gi|89242910 - gi|89242910|gb|ABD64728.1| AmphiHairyA [Branchiostoma floridae]
131.0 [0..1] [201..1]
gi|7228084 - gi|7228084|emb|CAB77019.1| HLHmgamma protein [Drosophila hydei]
130.0 [0..1] [205..1]
gi|1017761 - gi|1017761|gb|AAA79185.1| hairy1
127.0 [0..3] [205..22]

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Predicted Domain #1
Region A:
Residues: [1-112]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLQMSEMS KTYQYRKVMK PMLERKRRAR INKCLDELKD LMVATLESEG EHVTRLEKAD  60
   61 ILELTVTHLQ KMKQQRQHKR ASGDESLTPA EGFRSGYIHA VNEVSRSLSQ LP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.045757
Match: 1am9A
Description: SREBP-1a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
nucleic acid binding 5.05768805749761 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.39500382187264 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
transcription repressor activity 2.58751248599889 bayes_pls_golite062009
transcription activator activity 2.5495467409976 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.42306484786159 bayes_pls_golite062009
sequence-specific DNA binding 2.31910036997977 bayes_pls_golite062009
transcription corepressor activity 2.03674713048499 bayes_pls_golite062009
protein binding 1.59929864805879 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
promoter binding 0.8576109846276 bayes_pls_golite062009
transcription coactivator activity 0.3513586903977 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [113-205]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GMNVSLGTQL MTHLGQRLNQ IQPAEKEVLP VTAPLSVHIA NRDAYSVPIS PISSYAGSPN  60
   61 SNTSSTSHSL LTTIDVTKME DDSEDEENVW RPW

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle