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View Structure Prediction Details

Protein: HLHmdelta-PA
Organism: Drosophila melanogaster
Length: 173 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HLHmdelta-PA.

Description E-value Query
Range
Subject
Range
gi|1017761 - gi|1017761|gb|AAA79185.1| hairy1
132.0 [0..2] [172..20]
gi|37590864, gi|... - gi|37590864|gb|AAH59551.1| Her6 protein [Danio rerio], gi|169158177|emb|CAQ13541.1| hairy-related 6 ...
131.0 [0..2] [167..20]
gi|8078 - gi|8078|emb|CAA47433.1| helix-loop-helix protein [Drosophila melanogaster]
130.0 [0..1] [173..1]
HES4_XENTR - Transcription factor HES-4 OS=Xenopus tropicalis GN=hes4 PE=2 SV=1
130.0 [0..2] [164..21]
gi|47225756 - gi|47225756|emb|CAG08099.1| unnamed protein product [Tetraodon nigroviridis]
128.0 [0..2] [169..20]
gi|157278421, gi... - gi|66393604|gb|AAY45951.1| Her6.1 [Oryzias latipes], gi|157278421|ref|NP_001098313.1| Her6.1 [Oryzia...
128.0 [0..2] [169..20]
gi|55715459, gi|... - gi|55715459|gb|AAV59249.1| enhancer of split complex mdelta protein [Drosophila simulans], gi|557154...
128.0 [0..1] [173..1]

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Predicted Domain #1
Region A:
Residues: [1-173]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVQGQRFMT KTQHYRKVTK PLLERKRRAR MNLYLDELKD LIVDTMDAQG EQVSKLEKAD  60
   61 ILELTVNYLK AQQQQRVANP QSPPPDQVNL DKFRAGYTQA AYEVSHIFST VPGLDLKFGT 120
  121 HLMKQLGHQL KDMKQEEEII DMAEEPVNLA DQKRSKSPRE EDIHHGEEVW RPW

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.0
Match: 1am9A
Description: SREBP-1a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
nucleic acid binding 5.05768805749761 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.39500382187264 bayes_pls_golite062009
protein binding 2.64975291677725 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
transcription repressor activity 2.58751248599889 bayes_pls_golite062009
transcription activator activity 2.5495467409976 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.42306484786159 bayes_pls_golite062009
sequence-specific DNA binding 2.31910036997977 bayes_pls_golite062009
transcription corepressor activity 2.03674713048499 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
promoter binding 0.8576109846276 bayes_pls_golite062009
protein heterodimerization activity 0.53175615551166 bayes_pls_golite062009
transcription coactivator activity 0.3513586903977 bayes_pls_golite062009
protein dimerization activity 0.20674648626116 bayes_pls_golite062009

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