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View Structure Prediction Details

Protein: eIF4G2-PA, FBpp0...
Organism: Drosophila melanogaster
Length: 2072 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for eIF4G2-PA, FBpp0....

Description E-value Query
Range
Subject
Range
gi|23271675 - gi|23271675|gb|AAH23898.1| Eif4g3 protein [Mus musculus]
1007.0 [0..1081] [2072..31]

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Predicted Domain #1
Region A:
Residues: [1-238]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFPQQGGGGK GTRPQSTHQQ NHNHQAQHHQ ATHSHHHHLQ QQQEQQQSHA VFVPNHSGLH  60
   61 HHQQQHLLQQ QQQQHQQQAA VAAAHLQQHI QQQQQQQVQA QAQAHHQPVI FYNTQPSYAA 120
  121 HSAAVNNSAN GGGATLQLSA AASSNTLGHP LTGGHHGGAN GVAPGSNMPR ALSNPTLPPH 180
  181 FQQSAGLIAP AGGNAGGPYI SATYIPINQT GPLMGMQPAV TFPTNGAAGA SFYAAAPP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [239-409]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPQQKQLPPT AQQQGPGGAP GAAQTPTLAY YQLGPNAQNS AGNNVVSGAN THRGNMRGGQ  60
   61 RSTPTAQHTN YFTAYTMAPG NAQRPAPTNV APMMNSRSGA LNGAAAFHHL PHNFGIPSLA 120
  121 LGPPAGMTTP ILAPAGMQAP PPQPPGGLHT FAPHLQSNSA TTLPSVPSVT G

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [410-506]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPAVASGFST TSLPTPSVTT APQLGANSDK VCKRKYAIPI IHPDTMENVM DGWKRSVFIK  60
   61 KDSNSTLTQH TDLDTALDDN STLCLYQAPT LMDSGSG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [507-688]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSLLSGAMVD QQMQTVKPAS SLKQSVSLEK VPEAVYCKDA VGQDVHPSPP PKSTDKDQIS  60
   61 VIVKDILAHS GNAEDHLSFW QYSDVDNVTE THNSLPLVQS DLPDTTDTCQ QPVLFQEQAK 120
  121 KQRPKLANKQ STATPASIAN DVAEAAASGC PGVSILSRGQ SMVTPAGPST PPPPSRVAQQ 180
  181 KS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [689-895]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKSIVTTAVA ASVKPTTGSP NRKSSIQAAT STTTSSGASS STASTPTHAS SKLKQQPVNN  60
   61 LQHGKQIPGK VSTPALPPTA SRISAAVTLL AGTANITTTT NSSKKQRQAQ KRARELEKKK 120
  121 QKSSITSTTS TQGQNNNGKG NGNGNAALEI NTNSNNAATV TTTSMSTLTT TTTATAPTTK 180
  181 QETAAVDDKE TAQPTTDTLS ATSNNTK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [896-1117]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSSILRDKKT MLNPKEQLTS HNNNNNNNNE DGIEAKVESD PESDIKDDSM SNITGEKSEK  60
   61 HLANEEIVAK FLQKDSPDTS VVHAETQQLQ FLNSSSSVCE EDEPVPVISE GVTKTEENAE 120
  121 AEIKFGDFHE DPRNDTGFIC SSTWSSSTIS KAAEDDSSQS SRSADNVDCA PKVVEQISEE 180
  181 KSASSTKSSP VHKATGSGPG SPKTKELKSK SPSPIPVPQV PK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1118-1263]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NYRYSIETLR ELAKRRDSRK PPMVPCQKGD CISQLFVSRQ QQPQQHHGQH IQQYQHMSFN  60
   61 ESLDYVPGKR GRGHGPNKKH HDQHQQMGGS SGMGSGSGGG GGISNSSQRH MDIIRVQLSL 120
  121 KEEIKLSECE NAWQPGTLRR VSMAGG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1264-1588]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDEDDDVEGV LKKVRGILNK LTPDNFEVLL KEMSSIKMDN EAKMTNVMLL IFEKTISEPN  60
   61 FAPTYARFCK VLFHEIKAEN KSLFTSSLIT RIQHEFESNV NDANAKSKKL QPTMERINQC 120
  121 SDPAKKAELR AEMEDLEYQF RRRAWGTVRF IGELFKLQSL TNDRVLNCVE SLLEHGCEEK 180
  181 LEYMCKLLTT VGHLLESSLP EHYQLRDRIE KIFRRIQDII NRSRGTSHRQ QVHIKISSRV 240
  241 RFMMQDVLDL RLRNWDQPAT HQSGQQGGRG QRHKQHDDSK DQSHSTGGGR GGGMNQHQQS 300
  301 STHHQHQKHN QHGHDGGNYF MQKMP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 111.0
Match: 1hu3A
Description: Eukaryotic initiation factor eIF4G
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.373576425899935 bayes_pls_golite062009

Predicted Domain #9
Region A:
Residues: [1589-1689]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKQHHENQTL SIDPSKLRFS NSSATDDSIA KLGNSSHYQW RNVGNRPVSS TQVNASNAPP  60
   61 PTSLLKRPGQ NYKFLPYQQP SAVAGTANAP AGGNKSNVEV N

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #10
Region A:
Residues: [1690-2072]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DAFDGKQCQG LITKLVEEAL NTREWQPEVL SIWRSHSGSQ QSKTLFHLLT DYLHKSTVKR  60
   61 QHRQACGNIF AYLMDKDAVE KEIFEEAYSR FGDDFPDLLV DVPNGWGYVF EFLGPIIHSG 120
  121 HLDLKDVWQR RWLDDFFFAE RFVYAFVSYF VQEFGAAYAR KLWHNDYKLD RGQLFWSDVR 180
  181 KYREFVQSHS FYFLDNGPGQ NQGHAKVKAP TTPRSPVEHV ERIRHLLAIS CDMAIDYINT 240
  241 NVAINDKFVR QLTRFLCCDF ALTVMTNTHN NIKSGGNSKP LQLNTESFRS CCTPLLRLCI 300
  301 DAQEALEIAC IDEAVDALQQ HFMTEYEDDM AAGETICSTF SVLYESEVIP KESFDKWYKL 360
  361 EMAHSRAYRR PFIDKLRGFI EEM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 121.0
Match: 1ug3A
Description: C-terminal portion of human eIF4GI
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle