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View Structure Prediction Details

Protein: Eip93F-PA
Organism: Drosophila melanogaster
Length: 1165 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Eip93F-PA.

Description E-value Query
Range
Subject
Range
Eip93F-PB - The gene Eip93F is referred to in FlyBase by the symbol Dmel\Eip93F (CG18389, FBgn0013948). It is a ...
936.0 [0..8] [1165..31]

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Predicted Domain #1
Region A:
Residues: [1-159]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHISSYEISL ERVAEECMGR RQWKHYQDKL TCSHLNIEEQ QPIAIAGSED EPSQYNHSSK  60
   61 EISQSNPNHC KTENHRLEQQ HNGSQLLEEE DSENNQTSHD SSRTPTPGAT STPSPPPEPI 120
  121 DWRPSAKCNF CVNGRLLTVN AQGKLVAESA ATATSSSTS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [160-398]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSHIHQHDSD SNSSASLPHH ISSSSSSNNN SSGNRARHIA AASARATPAA ATPANSLELY  60
   61 KLLTQRAAKM TSMDSMAAQL AQFSLLADFN LINSLASQQQ QQQQQQIASA VTPTTSEVSA 120
  121 AAISPALKDT PSPSVDAPLD LSSKPSPNSS ISGDVKSVRA CATPTPSGRR AYSEEDLSRA 180
  181 LQDVVANKLD ARKSASQHHE QRSILDNRLF KMKHHDQEQD HDGDELEDSN DDAEAEVDS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [399-573]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NASTPVYPAE FARAQLRKLS HLSEHNGSDL GEDVDRGSPK MGRHPACGNA SANQGAPPSI  60
   61 PLDANVLLHT LMLAAGIGAM PKLDETQTVG DFIKGLLVAN SGGIMNEGLL NLLSASQENS 120
  121 NGNASLLLQQ QQHQQHHQQH HQQQQQQQHV AAYRHRLPKS ETPETNSSLD PNDAS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [574-758]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDPILKIPSF KVSGPASSSS LSPGGLVGGH HHPLNNNNSL SISNNSNHSS NSHRNGSNRS  60
   61 PHSASPMLAA AVAQGGYSAG NSLLTSSSSS IQKMMASNIQ RQINEQSGQE SLRNGNVSDC 120
  121 SSNNGGSSSL GYKKPSISVA KIIGGTDTSR FGASPNLLSQ QHHSAHHLTH QQQQQQLSAQ 180
  181 EALGK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [759-889]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTRPKRGKYR NYDRDSLVEA VKAVQRGEMS VHRAGSYYGV PHSTLEYKVK ERHLMRPRKR  60
   61 EPKPQPDLVG LTGPANKLQL DKLKAGPHGG SKLSNALKNQ NNQAAAAAAA AAAAAAAATP 120
  121 NGLKLPLFEA G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.30103
Match: 2cobA
Description: Solution structures of the HTH domain of human LCoR protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
sequence-specific DNA binding 3.5139760613123 bayes_pls_golite062009
transcription activator activity 3.10621734076555 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
protein binding 1.88087411289001 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 1.04132983826241 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 0.13444271681002 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [890-977]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQALSFQPNM FWPQTNATNA YGLDFNRITE AMRNPQASNH HGLMKSAQDM VENVYDGIIR  60
   61 KTLQASEGNG SAAGNGSNGS NGNGHGHG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [978-1052]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HGHGHALLDQ LLVKKTPLPF TNHRNNDYAA TCSSASGESV KRSGSPMGNY ADIKRERLSA  60
   61 DSGGSSDEEH SASHI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1053-1165]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNNNSDLAHN KNKSGGGGGG GGNGQTNGNG RSSRMTSRDD SETDASSLKS GESGGQQNHK  60
   61 MMDLNGGSSS SSHIKCESEA ATGHHSPGHH TTSILHEKLA QIKAEQVDQA DQL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle