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View Structure Prediction Details

Protein: htl-PB, htl-PA, ...
Organism: Drosophila melanogaster
Length: 729 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for htl-PB, htl-PA, ....

Description E-value Query
Range		 Subject
Range
FGFR2_CHICK - Fibroblast growth factor receptor 2 OS=Gallus gallus GN=FGFR2 PE=2 SV=1
 445.0 [0..1] [725..52]

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Predicted Domain #1
Region A:
Residues: [1-274] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAWSWRAS HSTITMTSGS LVVLFLLLSI WQPAVQVEGR RQMANSQEMI KDHLGARSQN  60
   61 KTPAITNNAN QSSTSSADLD DGAADDDDNK ADLPVNVSSK PYWRNPKKMS FLQTRPSGSL 120
  121 LTLNCHALGN PEPNITWYRN GTVDWTRGYG SLKRNRWTLT MEDLVPGDCG NYTCKVCNSL 180
  181 GCIRHDTQVI VSDRVNHKPI LMTGPLNLTL VVNSTGSMHC KYLSDLTSKK AWIFVPCHGM 240
  241 TNCSNNRSII AEDKDQLDFV NVRMEQEGWY TCVE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.522879
Match: 1ry7B
Description: Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
fibroblast growth factor 1 binding 6.68503380812062 bayes_pls_golite062009
receptor activity 4.00123250685257 bayes_pls_golite062009
transmembrane receptor activity 3.81769911097805 bayes_pls_golite062009
fibroblast growth factor binding 3.54458347746523 bayes_pls_golite062009
fibroblast growth factor receptor activity 3.20458334492494 bayes_pls_golite062009
binding 3.17641566810715 bayes_pls_golite062009
antigen binding 3.16266926144655 bayes_pls_golite062009
molecular transducer activity 3.10913345555941 bayes_pls_golite062009
signal transducer activity 3.10913345555941 bayes_pls_golite062009
peptide antigen binding 2.90974891147024 bayes_pls_golite062009
integrin binding 2.42680883711596 bayes_pls_golite062009
cytokine receptor activity 2.36139848096635 bayes_pls_golite062009
growth factor binding 2.28613301180608 bayes_pls_golite062009
protein binding 2.22855404705168 bayes_pls_golite062009
nucleic acid binding 1.72877697607698 bayes_pls_golite062009
transcription regulator activity 1.63661012317575 bayes_pls_golite062009
DNA binding 1.55059030140656 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 1.52958974617075 bayes_pls_golite062009
actin filament binding 1.47359288623575 bayes_pls_golite062009
protein kinase activity 1.36635494500222 bayes_pls_golite062009
transmembrane receptor protein kinase activity 1.30657787244536 bayes_pls_golite062009
G-protein coupled receptor activity 1.02428106476324 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.02286631988334 bayes_pls_golite062009
kinase activity 0.929878054374821 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.878595022643164 bayes_pls_golite062009
transcription factor activity 0.87842522681995 bayes_pls_golite062009
protein complex binding 0.83543827718565 bayes_pls_golite062009
peptide binding 0.729048089532569 bayes_pls_golite062009
receptor binding 0.632627479346393 bayes_pls_golite062009
cytokine binding 0.631436442105379 bayes_pls_golite062009
protein serine/threonine kinase activity 0.564762108830441 bayes_pls_golite062009
IgG binding 0.39801134339725 bayes_pls_golite062009
cytoskeletal protein binding 0.38670960441694 bayes_pls_golite062009
protein tyrosine kinase activity 0.318890055375093 bayes_pls_golite062009
olfactory receptor activity 0.20101044847022 bayes_pls_golite062009
actin binding 0.18356099709255 bayes_pls_golite062009
transferase activity 0.053007146193305 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [275-392] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNSLGQSNST AYLRVVRSLH VLEAGVASGS LHSTSFVYIF VFGGLIFIFM TTLFVFYAIR  60
   61 KMKHEKVLKQ RIETVHQWTK KVIIFKPEGG GDSSGSMDTM IMPVVRIQKQ RTTVLQNG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.69897
Match: 2nziA
Description: No description for 2nziA was found.

Predicted Domain #3
Region A:
Residues: [393-729] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NEPAPFNEYE FPLDSNWELP RSHLVLGATL GEGAFGRVVM AEVNNAIVAV KMVKEGHTDD  60
   61 DIASLVREME VMKIIGRHIN IINLLGCCSQ NGPLYVIVEY APHGNLKDFL YKNRPFGRDQ 120
  121 DRDSSQPPPS PPAHVITEKD LIKFAHQIAR GMDYLASRRC IHRDLAARNV LVSDDYVLKI 180
  181 ADFGLARDIQ STDYYRKNTN GRLPIKWMAP ESLQEKFYDS KSDVWSYGIL LWEIMTYGQQ 240
  241 PYPTIMSAEE LYTYLMSGQR MEKPAKCSMN IYILMRQCWH FNADDRPPFT EIVEYMDKLL 300
  301 QTKEDYLDVD IANLDTPPST SDEEEDETDN LQKWCNY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 74.09691
Match: 2pvfA
Description: No description for 2pvfA was found.
YRC Informatics Platform - Version 3.0
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