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View Structure Prediction Details

Protein: Rbf2-PA
Organism: Drosophila melanogaster
Length: 783 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Rbf2-PA.

Description E-value Query
Range
Subject
Range
gi|114649790 - gi|114649790|ref|XP_509777.2| PREDICTED: retinoblastoma 1 [Pan troglodytes]
776.0 [0..11] [779..198]

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Predicted Domain #1
Region A:
Residues: [1-168]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METCEVEGEA ETLVRRFSVS CEQLELEARI QQSALSTYHR LDAVNGLSTS EADAQEWLCC  60
   61 AVYSELQRSK MRDIRESINE ANDSVAKNCC WNVSLTRLLR SFKMNVSQFL RRMEHWNWLT 120
  121 QNENTFQLEV EELRCRLGIT STLLRHYKHI FRSLFVHPGK GADPGAAN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 38.69897
Match: 1c9bA
Description: Transcription factor IIB (TFIIB), core domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cyclin-dependent protein kinase regulator activity 4.0678067833198 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 3.72590522082801 bayes_pls_golite062009
protein kinase regulator activity 3.60228514328814 bayes_pls_golite062009
kinase regulator activity 3.4358680585811 bayes_pls_golite062009
transcription regulator activity 2.795846725429 bayes_pls_golite062009
binding 2.4204867358489 bayes_pls_golite062009
nucleic acid binding 2.04886889839181 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.00665312545368 bayes_pls_golite062009
DNA binding 1.94297811210385 bayes_pls_golite062009
protein binding 1.47106731485576 bayes_pls_golite062009
transcription repressor activity 1.42956126861466 bayes_pls_golite062009
transcription factor activity 1.21921365719206 bayes_pls_golite062009
transcription factor binding 0.749278791251235 bayes_pls_golite062009
enzyme regulator activity 0.729629809946521 bayes_pls_golite062009
transcription coactivator activity 0.138191616709499 bayes_pls_golite062009
transcription activator activity 0.0696060248241566 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [169-303]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HYQALYEFGW LLFLVIRNEL PGFAITNLIN GCQVLVCTMD LLFVNALEVP RSVVIRREFS  60
   61 GVPKNWDTED FNPILLNKYS VLEALGELIP ELPAKGVVQM KNAFFHKALI MLYMDHSLVG 120
  121 DDTHMREIIK EGMLD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [304-363]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INLENLNRKY TNQVADISEM DERVLLSVQG AIETKGDSPK SPQLAFQTSS SPSHRKLSTH  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [364-702]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLPASLPLSI IKAFPKKEDA DKIVNYLDQT LEEMNRTFTM AVKDFLDAEL SGKRFRQARG  60
   61 LYYKYLQKIL GPELVQKPQL KIGQLMKQRK LTAALLACCL ELALHVHHKL VEGLRFPFVL 120
  121 HCFSLDAYDF QKILELVVRY DHGFLGRELI KHLDVVEEMC LDSLIFRKSS QLWWELNQRL 180
  181 PRYKEVDAET EDKENFSTGS SICLRKFYGL ANRRLLLLCK SLCLVDSFPQ IWHLAEHSFT 240
  241 LESSRLLRNR HLDQLLLCAI HLHVRLEKLH LTFSMIIQHY RRQPHFRRSA YREVSLGNGQ 300
  301 TADIITFYNS VYVQSMGNYG RHLECAQTRK SLEESQSNV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 119.0
Match: 2r7gA
Description: No description for 2r7gA was found.

Predicted Domain #5
Region A:
Residues: [703-783]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GILTETTSNE LSMRANISIS SPPPPRVCQS GSCSSHPPSS PAASPLSLQS SPNVKRAASS  60
   61 NDLMREIKRP NILRRRQLSV I

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle