YRC Public Data Repository - Protein Structure Prediction

Protein:	CG9589-PA
Organism:	Drosophila melanogaster
Length:	253 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG9589-PA.

Description	E-value	Query Range	Subject Range
gi\|12655814 - gi\|12655814\|gb\|AAK00606.1\|AF221100_3 uroporphyrinogen III synthase/methyltransferase [Selenomonas ru...	246.0	[0..3]	[251..256]
gi\|71489436, gi\|... - gi\|71544542\|ref\|ZP_00665566.1\| Uroporphyrin-III C-methyltransferase, C-terminal [Syntrophobacter fum...	244.0	[0..3]	[251..250]
gi\|51245586, gi\|... - gi\|51245586\|ref\|YP_065470.1\| uroporphyrinogen III synthase/methyltransferase (HemD+CobA) [Desulfotal...	242.0	[0..3]	[251..259]
gi\|147677308, gi... - gi\|98661630\|dbj\|GAA01338.1\| unnamed protein product [Pelotomaculum thermopropionicum SI], gi\|1476773...	240.0	[0..3]	[251..251]
gi\|25315418 - pir\|\|AC2237 uroporphyrinogen III methylase [imported] - Nostoc sp. (strain PCC 7120) gi\|17230942, gi\|... - gi\|17230942\|ref\|NP_487490.1\| uroporphyrinogen III methylase [Nostoc sp. PCC 7120], gi\|17132583\|dbj\|B...	239.0	[0..3]	[251..258]
gi\|49235877, gi\|... - gi\|83590096\|ref\|YP_430105.1\| uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthas...	239.0	[0..3]	[252..253]
gi\|88945102, gi\|... - gi\|88945102\|ref\|ZP_01148322.1\| Uroporphyrin-III C-methyltransferase, C-terminal [Desulfotomaculum re...	239.0	[0..3]	[251..253]
gi\|109645297, gi... - gi\|68208394\|ref\|ZP_00560513.1\| Uroporphyrin-III C-methyltransferase, C-terminal [Desulfitobacterium ...	238.0	[0..3]	[251..251]
gi\|117927445, gi... - gi\|88932190\|ref\|ZP_01137882.1\| uroporphyrin-III C-methyltransferase / uroporphyrinogen-III synthase ...	238.0	[0..3]	[251..245]
gi\|23125855, gi\|... - gi\|23125855\|ref\|ZP_00107772.1\| COG1587: Uroporphyrinogen-III synthase [Nostoc punctiforme PCC 73102]...	237.0	[0..3]	[251..268]

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Predicted Domain #1

Region A:
Residues: [1-253]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGDRNKQPVI LLKVPSSDDF YGSALRSHNL DPIFITPSHF VFKNLKQLQA KLHEPHKYAG  60
   61 IIFASPRCVQ AVNEALGKTP LPSCWRALHN YSLGKNTHSA AWITFQNLPT LGDHAVNANN 120
  121 LCDLIVETFG PKRDLPLLMP CGNGVGQTLR LRLVAQGFRV DACEVYESRS HPDFVNQMRH 180
  181 ALKFKRMETI VFFGPSSVRS SLEFFGNYNV SLKDRKLIAV GSGTRKAMEE SGIKADGVVN 240
  241 AADVDRLINI IKT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	47.154902
Match:	1jr2A
Description:	Uroporphyrinogen III synthase (U3S, HemD)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
uroporphyrinogen-III synthase activity	3.75954315324218	bayes_pls_golite062009
catalytic activity	1.13824203225664	bayes_pls_golite062009
binding	0.967564107266709	bayes_pls_golite062009
hydro-lyase activity	0.290711782955013	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: