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View Structure Prediction Details

Protein: hth-PC
Organism: Drosophila melanogaster
Length: 487 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hth-PC.

Description E-value Query
Range
Subject
Range
hth-PA - The gene homothorax is referred to in FlyBase by the symbol Dmel\hth (CG17117, FBgn0001235). It is a...
412.0 [0..1] [487..1]

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Predicted Domain #1
Region A:
Residues: [1-99]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQPRYDDGL HGYGMDSGAA AAAMYDPHAG HRPPGLQGLP SHHSPHMTHA AAAAATVGMH  60
   61 GYHSGAGGHG TPSHVSPVGN HLMGAIPEVH KRDKDAIYE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [100-214]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HPLFPLLALI FEKCELATCT PREPGVQGGD VCSSESFNED IAMFSKQIRS QKPYYTADPE  60
   61 VDSLMVQAIQ VLRFHLLELE KVHELCDNFC HRYISCLKGK MPIDLVIDER DTTKP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [215-347]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PELGSANGEG RSNADSTSHT DGASTPDVRP PSSSLSYGGA MNDDARSPGA GSTPGPLSQQ  60
   61 PPALDTSDPD GKFLSSLNPS ELTYDGRWCR REWSSPADAR NADASRRLYS SVFLGSPDNF 120
  121 GTSASGDASN ASI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [348-487]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSGEGTGEED DDASGKKNQK KRGIFPKVAT NILRAWLFQH LTHPYPSEDQ KKQLAQDTGL  60
   61 TILQVNNWFI NARRRIVQPM IDQSNRAVYT PHPGPSGYGH DAMGYMMDSQ AHMMHRPPGD 120
  121 PGFHQGYPHY PPAEYYGQHL 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.0
Match: 1x2nA
Description: Solution structure of the homeobox domain of human homeobox protein PKNOX1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle