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View Structure Prediction Details

Protein: MBD-like-PB
Organism: Drosophila melanogaster
Length: 226 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MBD-like-PB.

Description E-value Query
Range
Subject
Range
MBD3 - methyl-CpG binding domain protein 3
gi|55647849 - gi|55647849|ref|XP_512241.1| PREDICTED: methyl-CpG binding domain protein 3 isoform 2 [Pan troglodyt...
320.0 [0..9] [224..1]
gi|109122751 - gi|109122751|ref|XP_001095979.1| PREDICTED: similar to methyl-CpG binding domain protein 3 [Macaca m...
320.0 [0..9] [224..1]
gi|73987317, gi|... - gi|73987325|ref|XP_868594.1| PREDICTED: similar to methyl-CpG binding domain protein 3 isoform 5 [Ca...
319.0 [0..9] [224..1]
gi|47215634 - gi|47215634|emb|CAG01351.1| unnamed protein product [Tetraodon nigroviridis]
319.0 [0..9] [224..1]
gi|109507519 - gi|109507519|ref|XP_001069159.1| PREDICTED: similar to Methyl-CpG-binding domain protein 2 (Methyl-C...
317.0 [0..5] [224..217]
gi|24210495 - gi|24210495|dbj|BAC22082.1| methyl-CpG binding protein MBD3 [Xenopus laevis]
316.0 [0..9] [224..1]
MBD3_MOUSE - Methyl-CpG-binding domain protein 3 OS=Mus musculus GN=Mbd3 PE=1 SV=1
gi|5731992 - gi|5731992|gb|AAD48909.1|AF120995_1 methyl-CpG binding domain-containing protein 3 [Mus musculus dom...
gi|55715962 - gb|AAH86183.1| Unknown (protein for MGC:98642) [Xenopus laevis]
315.0 [0..9] [224..1]
gi|114673225 - gi|114673225|ref|XP_512139.2| PREDICTED: similar to methyl-CpG binding protein MBD2 [Pan troglodytes...
313.0 [0..5] [224..217]

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Predicted Domain #1
Region A:
Residues: [1-132]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQMNPSVTIE RKRVDCSVLP KGWQRDEVRK SGSSANNNAS SNNNSSATAS SNNNNNKVDV  60
   61 FYYSRALRTD VSLVPPIRQT ASIFKQPVTV IRNHKQDPAK AKNEPKHGTR EKPKQLFWEK 120
  121 RLERLRACHD SG

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.29
Match: 1ub1A
Description: Solution structure of the matrix attachment region-binding domain of chicken MeCP2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 4.18760591157176 bayes_pls_golite062009
nucleic acid binding 4.12220776678979 bayes_pls_golite062009
methyl-CpG binding 3.81156414745943 bayes_pls_golite062009
unmethylated CpG binding 3.56370738937072 bayes_pls_golite062009
double-stranded methylated DNA binding 3.47824441288235 bayes_pls_golite062009
transcription repressor activity 3.00772108352827 bayes_pls_golite062009
binding 2.93005095571864 bayes_pls_golite062009
transcription regulator activity 2.91932005830918 bayes_pls_golite062009
chromatin binding 2.64216199141626 bayes_pls_golite062009
transcription corepressor activity 2.3950556138867 bayes_pls_golite062009
transcription factor activity 2.17686009706401 bayes_pls_golite062009
sequence-specific DNA binding 2.16634466999037 bayes_pls_golite062009
transcription factor binding 1.48884995645619 bayes_pls_golite062009
protein binding 1.38597557698861 bayes_pls_golite062009
transcription cofactor activity 1.3122042592049 bayes_pls_golite062009
DNA secondary structure binding 1.05571990737816 bayes_pls_golite062009
four-way junction DNA binding 0.683632613559968 bayes_pls_golite062009
nucleotide binding 0.283389600803272 bayes_pls_golite062009
RNA binding 0.186168111758276 bayes_pls_golite062009
mRNA binding 0.0296015059393313 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [133-226]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EELDDISLPK TIRTVGPNVN EQTVLQSVAT ALHMLNAGVH GQSSTKADLT KNAMAFMNPE  60
   61 QPLMHAVIIS EDDIRKQEDR VGVARRKLQD ALKT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.316 N/A N/A a.11.1 Acyl-CoA binding protein
View Download 0.266 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.239 N/A N/A d.15.6 Superantigen toxins, C-terminal domain
View Download 0.239 N/A N/A a.39.1 EF-hand


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle