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View Structure Prediction Details

Protein: sage-PA, FBpp0312049
Organism: Drosophila melanogaster
Length: 268 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sage-PA, FBpp0312049.

Description E-value Query
Range
Subject
Range
gi|468497, gi|21... - gi|468497|emb|CAA82775.1| MITF protein [Homo sapiens], gi|4557755|ref|NP_000239.1| microphthalmia-as...
128.0 [0..11] [250..52]
gi|50979188, gi|... - gi|50979188|ref|NP_001003337.1| microphthalmia-associated transcription factor [Canis lupus familiar...
127.0 [0..11] [250..52]
gi|114587816 - gi|114587816|ref|XP_001138431.1| PREDICTED: microphthalmia-associated transcription factor isoform 4...
127.0 [0..11] [250..52]
gi|19072730 - gi|19072730|gb|AAL84610.1|AF475090_1 microphtalmia-associated transcription factor MITF-M [Xiphophor...
125.0 [0..30] [250..37]
gi|68445602, gi|... - gi|83921627|ref|NP_001033090.1| microphthalmia-associated transcription factor [Sus scrofa], gi|6844...
123.0 [0..11] [250..52]
gi|47564056, gi|... - gi|47564056|ref|NP_001001150.1| microphthalmia-associated transcription factor isoform M- [Bos tauru...
122.0 [0..11] [250..52]

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Predicted Domain #1
Region A:
Residues: [1-170]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDQLLSSTA GVPGDPPPVL VPVSATTGGP YLSGGSEGEA ESSEQPVLLE LGAPQSSSCP  60
   61 AVSLNYTLTA DGAGLLAYAP THPHSYSPSV MGGYEKEAHN MGLLPPTYSV IPQPVSMWHA 120
  121 GQVATGSPVG LECNKPSELV PPPMYMSYSG GSIANSTEVD IAKEHNPAWR 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [171-268]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKALQMEKDY RRTACDRERT RMRDMNRAFD LLRSKLPISK PNGKKYSKIE SLRIAINYIN  60
   61 HLQAMLRESS VGQNGNGCCA WSGGSSSPYD NGNDHWGA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.69897
Match: 1nkpA
Description: Myc prot-oncogene protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
nucleic acid binding 4.75270293029792 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
transcription activator activity 2.5495467409976 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.48787404513864 bayes_pls_golite062009
sequence-specific DNA binding 2.31910036997977 bayes_pls_golite062009
protein binding 1.59929864805879 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 1.46304579811572 bayes_pls_golite062009
transcription repressor activity 0.955588849035129 bayes_pls_golite062009
transcription corepressor activity 0.801830750183111 bayes_pls_golite062009
transcription coactivator activity 0.3513586903977 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle