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View Structure Prediction Details

Protein: Scr-PA, Scr-PB
Organism: Drosophila melanogaster
Length: 417 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Scr-PA, Scr-PB.

Description E-value Query
Range
Subject
Range
gi|798833 - gi|798833|emb|CAA54348.1| unnamed protein product [Drosophila melanogaster]
127.0 [0..1] [417..1]

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Predicted Domain #1
Region A:
Residues: [1-132]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDPDCFAMSS YQFVNSLASC YPQQMNPQQN HPGAGNSSAG GSGGGAGGSG GVVPSGGTNG  60
   61 GQGSAGAATP GANDYFPAAA AYTPNLYPNT PQAHYANQAA YGGQGNPDMV DYTQLQPQRL 120
  121 LLQQQQQQQQ QQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.69897
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [133-322]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HAHAAAAVAA QQQQQLAQQQ HPQQQQQQQQ ANISCKYAND PVTPGGSGGG GVSGSNNNNN  60
   61 SANSNNNNSQ SLASPQDLST RDISPKLSPS SVVESVARSL NKGVLGGSLA AAAAAAGLNN 120
  121 NHSGSGVSGG PGNVNVPMHS PGGGDSDSES DSGNEAGSSQ NSGNGKKNPP QIYPWMKRVH 180
  181 LGTSTVNANG 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [323-417]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETKRQRTSYT RYQTLELEKE FHFNRYLTRR RRIEIAHALC LTERQIKIWF QNRRMKWKKE  60
   61 HKMASMNIVP YHMGPYGHPY HQFDIHPSQF AHLSA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.154902
Match: 1homA
Description: DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle