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View Structure Prediction Details

Protein: MTA1-like-PB
Organism: Drosophila melanogaster
Length: 844 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MTA1-like-PB.

Description E-value Query
Range
Subject
Range
MTA1-like-PA - The gene MTA1-like is referred to in FlyBase by the symbol Dmel\MTA1-like (CG2244, FBgn0027951). It ...
645.0 [0..1] [844..1]

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Predicted Domain #1
Region A:
Residues: [1-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATNMYRVGD YVYVETTPNS PYLIRRIEEL NKNQTGNVEA KVMCFYRRRD LPNPLVQLAD  60
   61 KHQPALDEER TSPTQTSGGG GSATGNSGSN SSGTSNNNSS STAIGGGAGG SGGAGGDAEK 120
  121 GEALTSKQRY QIKHRELFLS RQVESIPATQ IRGKCSVTLL NETESLQSYL NKDDTFFYCL 180
  181 VFDPNQKTLL ADKGEIRVGS RYQCDIPAKL KDTAT

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.72
Match: 1w4sA
Description: Crystal structure of the proximal BAH domain of polybromo
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [216-322]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDRKLEELES LVWTPEHSLT DRKIDQFLVV SRSIGTFARA LDCSSSVKQP SLHMSAAAAS  60
   61 RDITLFHAMN ILHKHEYSIE ESMSSLVPST GPVLCRDEIE DWSASEA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [323-372]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLFEEALEKY GKDFNDIRQD FLPWKTLKQI IEYYYMWKTT DRYVQQKRVK 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.221849
Match: 2crgA
Description: Solution structure of the myb-like DNA-binding domain of mouse MTA3 protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.87991790206998 bayes_pls_golite062009
transcription regulator activity 2.122580758085 bayes_pls_golite062009
DNA binding 1.98453325263719 bayes_pls_golite062009
nucleic acid binding 1.93681952439958 bayes_pls_golite062009
transcription factor activity 1.36872096268289 bayes_pls_golite062009
protein deacetylase activity 1.30097338817679 bayes_pls_golite062009
histone deacetylase activity 1.21500914041004 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.09150919349912 bayes_pls_golite062009
sequence-specific DNA binding 1.03881604759993 bayes_pls_golite062009
protein binding 1.03780839342631 bayes_pls_golite062009
deacetylase activity 0.690301184840273 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.187173982490585 bayes_pls_golite062009
transcription activator activity 0.174325083775401 bayes_pls_golite062009
transcription factor binding 0.14097776282047 bayes_pls_golite062009
chromatin binding 0.123933030155299 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [373-604]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AVEAELKLKQ VYIPQYNNNG KGNGTSTKAG GGIYNGTTNG STDLSSNGKP CESCGTTKSS  60
   61 QWNSVSSGHS TSRLCLSCWE YWRRYGSMKS ATKGDAGEGD AKKKSSSAAS TPTATLAGLA 120
  121 TTPTAVVDLN DDEKISDLTN RQLHRCSIVN CGKEFKLKTH LARHYAQAHG IAISSGSPRP 180
  181 IMKTRTAFYL HTNPMTRVAR AICRSIVKPK KAARQSAYAI NAMLVKQEFT NR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [605-764]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISGKSQAEIK KLLLLKPKDR GSVTKIANRL GAPGSGPHEW LVLTPKDKMP LPAVVSFPKP  60
   61 PKAPDGSLVY DRVPNKSPDV VAVPADKELT IIPTQATSTI RKRAHEDQQL NGTEVTIVPS 120
  121 GPPAKRPNKD PMPSHCPSPE QFAAMMAASG QPLSRHHLNG 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [765-844]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KQKIAQMARG GNGRKQVISW MDAPDDVYFR ANDTHKKTRK ILSAVDLRRA ARKPWRTLPI  60
   61 KPAAPEPSSR PIESQIVILD 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


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