YRC Public Data Repository - Protein Structure Prediction

Protein:	Prosbeta7-PA, Pr...
Organism:	Drosophila melanogaster
Length:	268 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Prosbeta7-PA, Pr....

Description	E-value	Query Range	Subject Range
PSMA_METKA - Proteasome subunit alpha OS=Methanopyrus kandleri GN=psmA PE=3 SV=1 PSA_METKA - Proteasome subunit alpha OS=Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) ...	235.0	[0..29]	[257..4]
PSA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=psmA PE=3 SV=1 PSMA_PYRAB - Proteasome subunit alpha OS=Pyrococcus abyssi GN=psmA PE=3 SV=1	228.0	[0..30]	[257..5]
PSA_PYRFU - Proteasome subunit alpha OS=Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) GN=p... PSMA_PYRFU - Proteasome subunit alpha OS=Pyrococcus furiosus GN=psmA PE=3 SV=1	227.0	[0..30]	[258..5]
PSA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC ... PSMA_PYRHO - Proteasome subunit alpha OS=Pyrococcus horikoshii GN=psmA PE=3 SV=1	226.0	[0..30]	[258..5]
gi\|116283481 - gi\|116283481\|gb\|AAH14999.1\| PSMA7 protein [Homo sapiens]	226.0	[0..33]	[267..1]
gi\|74145096 - gi\|74145096\|dbj\|BAE27417.1\| unnamed protein product [Mus musculus]	223.0	[0..33]	[260..1]
PSA4_SPIOL - Proteasome subunit alpha type-4 OS=Spinacia oleracea GN=PAC1 PE=2 SV=1	223.0	[0..32]	[256..2]
PSA_METMP - Proteasome subunit alpha OS=Methanococcus maripaludis (strain S2 / LL) GN=psmA PE=3 SV=1 PSMA_METMP - Proteasome subunit alpha OS=Methanococcus maripaludis GN=psmA PE=3 SV=1	222.0	[0..31]	[266..6]
PSMA_METJA - Proteasome subunit alpha OS=Methanocaldococcus jannaschii GN=psmA PE=1 SV=1 PSA_METJA - Proteasome subunit alpha OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JC...	222.0	[0..31]	[254..5]
PSMA_ARCFU - Proteasome subunit alpha OS=Archaeoglobus fulgidus GN=psmA PE=1 SV=1 PSA_ARCFU - Proteasome subunit alpha OS=Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 ...	222.0	[0..28]	[267..1]

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Predicted Domain #1

Region A:
Residues: [1-268]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLNNYNSLAQ PMWQNGPAPG EFYNFTGGQT PVQQLPRELT TMGPYGTKHS TASSTTGTSV  60
   61 LGIRYDSGVM LAADTLVSYG SMARYQNIER VFKVNKNILL GGSGDFADIQ SIKRNIDQKM 120
  121 IEDQCCDDNI EMKPKSLASW MTRVLYNRRS RMNPLYIDVV VGGVDNEGTP YLANVDLRGR 180
  181 SYEDYVVATG FARHLAVPLV REKKPKDRDF TAVEASELIR TCMEVLYYRD TRNISQYTVG 240
  241 VCSVNGCGVE GPFQVNENWT FAETIKGY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	45.39794
Match:	1iruN
Description:	Proteasome beta subunit (catalytic)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
endopeptidase activity	6.91642761177919	bayes_pls_golite062009
peptidase activity	6.84511694091156	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	6.5973571808298	bayes_pls_golite062009
hydrolase activity	4.47652590304822	bayes_pls_golite062009
threonine-type endopeptidase activity	2.98214579292788	bayes_pls_golite062009
threonine-type peptidase activity	2.98214579292788	bayes_pls_golite062009
binding	1.75265921676176	bayes_pls_golite062009
nucleic acid binding	1.39216781236247	bayes_pls_golite062009
catalytic activity	1.19663085909195	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: